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• W2072337863 abstract "Variation in dopamine receptor levels has been associated with different facets of impulsivity. To further delineate the neural substrates underlying impulsive action (inability to withhold a prepotent motor response) and impulsive choice (delay aversion), we characterised rats in the Differential Reinforcement of Low Rates of Responding task and a delay discounting task. We also measured performance on an effort-based discounting task. We then assessed D1 and D2 dopamine receptor mRNA expression in subregions of the prefrontal cortex and nucleus accumbens using in situ hybridisation, and compared these data with behavioral performance. Expression of D1 and D2 receptor mRNA in distinct brain regions was predictive of impulsive action. A dissociation within the nucleus accumbens was observed between subregions and receptor subtypes; higher D1 mRNA expression in the shell predicted greater impulsive action, whereas lower D2 mRNA expression in the core predicted greater impulsive action. We also observed a negative correlation between impulsive action and D2 mRNA expression in the prelimbic cortex. Interestingly, a similar relationship was present between impulsive choice and prelimbic cortex D2 mRNA, despite the fact that behavioral indices of impulsive action and impulsive choice were uncorrelated. Finally, we found that both high D1 mRNA expression in the insular cortex and low D2 mRNA expression in the infralimbic cortex were associated with willingness to exert effort for rewards. Notably, dopamine receptor mRNA in these regions was not associated with either facet of impulsivity. The data presented here provide novel molecular and neuroanatomical distinctions between different forms of impulsivity, as well as effort-based decision-making." @default.
• W2072337863 created "2016-06-24" @default.
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• W2072337863 date "2013-03-20" @default.
• W2072337863 modified "2023-10-04" @default.
• W2072337863 title "Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity" @default.
• W2072337863 cites W1764010569 @default.
• W2072337863 cites W1895018411 @default.
• W2072337863 cites W1964544901 @default.
• W2072337863 cites W1966384929 @default.
• W2072337863 cites W1968886404 @default.
• W2072337863 cites W1970282176 @default.
• W2072337863 cites W1973466311 @default.
• W2072337863 cites W1977727477 @default.
• W2072337863 cites W1978443369 @default.
• W2072337863 cites W1983332126 @default.
• W2072337863 cites W1986566435 @default.
• W2072337863 cites W1988038665 @default.
• W2072337863 cites W1990385430 @default.
• W2072337863 cites W1991281276 @default.
• W2072337863 cites W1991471569 @default.
• W2072337863 cites W1991542370 @default.
• W2072337863 cites W1992317055 @default.
• W2072337863 cites W1998461664 @default.
• W2072337863 cites W2002230039 @default.
• W2072337863 cites W2004173362 @default.
• W2072337863 cites W2004730356 @default.
• W2072337863 cites W2005427299 @default.
• W2072337863 cites W2007001183 @default.
• W2072337863 cites W2008233347 @default.
• W2072337863 cites W2008413772 @default.
• W2072337863 cites W2010152698 @default.
• W2072337863 cites W2010797301 @default.
• W2072337863 cites W2017588448 @default.
• W2072337863 cites W2020406157 @default.
• W2072337863 cites W2021190392 @default.
• W2072337863 cites W2026944484 @default.
• W2072337863 cites W2026950073 @default.
• W2072337863 cites W2028127185 @default.
• W2072337863 cites W2029087047 @default.
• W2072337863 cites W2031048386 @default.
• W2072337863 cites W2033938510 @default.
• W2072337863 cites W2034480183 @default.
• W2072337863 cites W2041421155 @default.
• W2072337863 cites W2041697442 @default.
• W2072337863 cites W2044006215 @default.
• W2072337863 cites W2044346852 @default.
• W2072337863 cites W2051994215 @default.
• W2072337863 cites W2054111217 @default.
• W2072337863 cites W2060946807 @default.
• W2072337863 cites W2063281891 @default.
• W2072337863 cites W2064180977 @default.
• W2072337863 cites W2065237565 @default.
• W2072337863 cites W2065494210 @default.
• W2072337863 cites W2068210401 @default.
• W2072337863 cites W2069261271 @default.
• W2072337863 cites W2074006378 @default.
• W2072337863 cites W2076316947 @default.
• W2072337863 cites W2080142950 @default.
• W2072337863 cites W2081230121 @default.
• W2072337863 cites W2082078342 @default.
• W2072337863 cites W2087874796 @default.
• W2072337863 cites W2088475596 @default.
• W2072337863 cites W2092305976 @default.
• W2072337863 cites W2094127572 @default.
• W2072337863 cites W2097559385 @default.
• W2072337863 cites W2102814872 @default.
• W2072337863 cites W2113324723 @default.
• W2072337863 cites W2118475046 @default.
• W2072337863 cites W2123450218 @default.
• W2072337863 cites W2125080419 @default.
• W2072337863 cites W2127619757 @default.
• W2072337863 cites W2128167875 @default.
• W2072337863 cites W2128342589 @default.
• W2072337863 cites W2130969546 @default.
• W2072337863 cites W2134454471 @default.
• W2072337863 cites W2139302013 @default.
• W2072337863 cites W2141536473 @default.
• W2072337863 cites W2142464125 @default.
• W2072337863 cites W2142802442 @default.
• W2072337863 cites W2144902188 @default.
• W2072337863 cites W2146220657 @default.
• W2072337863 cites W2148537626 @default.
• W2072337863 cites W2149354807 @default.
• W2072337863 cites W2162839222 @default.
• W2072337863 cites W2165310823 @default.
• W2072337863 cites W2165845471 @default.
• W2072337863 cites W2166189176 @default.
• W2072337863 cites W2167420848 @default.
• W2072337863 cites W4320801407 @default.
• W2072337863 doi "https://doi.org/10.1111/ejn.12191" @default.
• W2072337863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3973541" @default.
• W2072337863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23510331" @default.

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