FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072338892> ?p ?o ?g. }

• W2072338892 endingPage "460" @default.
• W2072338892 startingPage "453" @default.
• W2072338892 abstract "The Tec family tyrosine kinase, Itk, was initially characterized as a crucial component of T-cell receptor signaling pathways resulting in phospholipase C-γ1 activation and actin polymerization. In 1999, a seminal report by Fowell, Locksley and colleagues demonstrated that, in CD4+ T cells, Itk-dependent signals are differentially required for T-helper (Th)2 versus Th1 differentiation and effector function. These findings launched a series of in vitro and in vivo studies addressing the molecular defects of Itk−/− CD4+ T cells, and the impaired immune responses of intact Itk-deficient mice. While demonstrating a bias against Th2 differentiation, overall these experiments have indicated that the most significant failing is an inability of Itk−/− CD4+ T cells to produce Th2 cytokines in a recall response, rather than an absolute defect in Th2 differentiation by T cells lacking Itk. In this review, we discuss the pathways by which Itk might impact the differentiation of Th cells. The Tec family tyrosine kinase, Itk, was initially characterized as a crucial component of T-cell receptor signaling pathways resulting in phospholipase C-γ1 activation and actin polymerization. In 1999, a seminal report by Fowell, Locksley and colleagues demonstrated that, in CD4+ T cells, Itk-dependent signals are differentially required for T-helper (Th)2 versus Th1 differentiation and effector function. These findings launched a series of in vitro and in vivo studies addressing the molecular defects of Itk−/− CD4+ T cells, and the impaired immune responses of intact Itk-deficient mice. While demonstrating a bias against Th2 differentiation, overall these experiments have indicated that the most significant failing is an inability of Itk−/− CD4+ T cells to produce Th2 cytokines in a recall response, rather than an absolute defect in Th2 differentiation by T cells lacking Itk. In this review, we discuss the pathways by which Itk might impact the differentiation of Th cells." @default.
• W2072338892 created "2016-06-24" @default.
• W2072338892 creator A5052781798 @default.
• W2072338892 creator A5061890829 @default.
• W2072338892 creator A5069136051 @default.
• W2072338892 date "2006-10-01" @default.
• W2072338892 modified "2023-10-15" @default.
• W2072338892 title "Itk and Th2 responses: action but no reaction" @default.
• W2072338892 cites W1480439893 @default.
• W2072338892 cites W1484685014 @default.
• W2072338892 cites W1506430118 @default.
• W2072338892 cites W1536647909 @default.
• W2072338892 cites W1559516752 @default.
• W2072338892 cites W1562527353 @default.
• W2072338892 cites W1894231348 @default.
• W2072338892 cites W1912392256 @default.
• W2072338892 cites W1914716732 @default.
• W2072338892 cites W1921076722 @default.
• W2072338892 cites W1929479237 @default.
• W2072338892 cites W1951217465 @default.
• W2072338892 cites W1969319369 @default.
• W2072338892 cites W1970772098 @default.
• W2072338892 cites W1974356101 @default.
• W2072338892 cites W1974595919 @default.
• W2072338892 cites W1982370494 @default.
• W2072338892 cites W1987146610 @default.
• W2072338892 cites W2015695515 @default.
• W2072338892 cites W2027139443 @default.
• W2072338892 cites W2028842451 @default.
• W2072338892 cites W2029220604 @default.
• W2072338892 cites W2034946023 @default.
• W2072338892 cites W2037398046 @default.
• W2072338892 cites W2038271225 @default.
• W2072338892 cites W2041215937 @default.
• W2072338892 cites W2041437399 @default.
• W2072338892 cites W2042616736 @default.
• W2072338892 cites W2047062588 @default.
• W2072338892 cites W2051810870 @default.
• W2072338892 cites W2052690081 @default.
• W2072338892 cites W2053463045 @default.
• W2072338892 cites W2053633405 @default.
• W2072338892 cites W2053701855 @default.
• W2072338892 cites W2053768146 @default.
• W2072338892 cites W2061625698 @default.
• W2072338892 cites W2067500883 @default.
• W2072338892 cites W2072013743 @default.
• W2072338892 cites W2074049880 @default.
• W2072338892 cites W2076557287 @default.
• W2072338892 cites W2091039798 @default.
• W2072338892 cites W2092972397 @default.
• W2072338892 cites W2095607685 @default.
• W2072338892 cites W2096118127 @default.
• W2072338892 cites W2100699905 @default.
• W2072338892 cites W2103890955 @default.
• W2072338892 cites W2106706493 @default.
• W2072338892 cites W2108888172 @default.
• W2072338892 cites W2114651496 @default.
• W2072338892 cites W2122503612 @default.
• W2072338892 cites W2124116262 @default.
• W2072338892 cites W2124458096 @default.
• W2072338892 cites W2126705913 @default.
• W2072338892 cites W2128181270 @default.
• W2072338892 cites W2132529497 @default.
• W2072338892 cites W2133654601 @default.
• W2072338892 cites W2137210893 @default.
• W2072338892 cites W2141513359 @default.
• W2072338892 cites W2141895910 @default.
• W2072338892 cites W2142899869 @default.
• W2072338892 cites W2143521765 @default.
• W2072338892 cites W2145518214 @default.
• W2072338892 cites W2149748445 @default.
• W2072338892 cites W2150564865 @default.
• W2072338892 cites W2161036104 @default.
• W2072338892 cites W2162001241 @default.
• W2072338892 cites W2164349125 @default.
• W2072338892 cites W2164692566 @default.
• W2072338892 cites W2167854031 @default.
• W2072338892 cites W2168476212 @default.
• W2072338892 cites W2168860308 @default.
• W2072338892 cites W4313335791 @default.
• W2072338892 doi "https://doi.org/10.1016/j.it.2006.08.006" @default.
• W2072338892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16931156" @default.
• W2072338892 hasPublicationYear "2006" @default.
• W2072338892 type Work @default.
• W2072338892 sameAs 2072338892 @default.
• W2072338892 citedByCount "33" @default.
• W2072338892 countsByYear W20723388922012 @default.
• W2072338892 countsByYear W20723388922013 @default.
• W2072338892 countsByYear W20723388922014 @default.
• W2072338892 countsByYear W20723388922015 @default.
• W2072338892 countsByYear W20723388922016 @default.
• W2072338892 countsByYear W20723388922017 @default.
• W2072338892 countsByYear W20723388922018 @default.
• W2072338892 countsByYear W20723388922020 @default.
• W2072338892 countsByYear W20723388922023 @default.
• W2072338892 crossrefType "journal-article" @default.
• W2072338892 hasAuthorship W2072338892A5052781798 @default.
• W2072338892 hasAuthorship W2072338892A5061890829 @default.

• next