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- W2072339938 abstract "Significance Whether breast cancer will respond to the antiestrogen tamoxifen is determined by whether cellular proliferation is estrogen receptor (ER) α-mediated. As opposed to early ductal cancer, which is an ERα-rich, proliferating disease, in early lobular cancer both ERα and ERβ are abundantly expressed and proliferation is rare. In advanced lobular cancer, ERβ is lost, ERα is retained, and proliferation is high. Thus, tamoxifen may be an effective pharmaceutical in late but not early lobular cancer." @default.
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- W2072339938 date "2014-01-21" @default.
- W2072339938 modified "2023-10-16" @default.
- W2072339938 title "Differential expression of estrogen receptor α, β1, and β2 in lobular and ductal breast cancer" @default.
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- W2072339938 doi "https://doi.org/10.1073/pnas.1323719111" @default.
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