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- W2072349276 abstract "The development of antiretroviral drug resistance is a major threat to the effective treatment of human immunodeficiency virus type 1 (HIV-1) infection. Drug treatment failure is associated with accumulation of drug resistance mutations and the evolution of drug resistance. Studies from microbial systems provide evidence for a correlation between drug resistance development and increased pathogen mutation rates. Recent studies with HIV-1 have shown that drugs targeted against reverse transcriptase (RT) as well as drug-resistant RT can increase HIV-1 mutation frequencies. Furthermore, combinations of drug and drug-resistant RT have been found to increase virus mutation frequencies in a multiplicative manner. The correlation of increased HIV-1 mutation rates with the evolution of antiretroviral drug resistance indicates that drug failure could increase the likelihood of further resistance evolving from subsequent drug regimens." @default.
- W2072349276 created "2016-06-24" @default.
- W2072349276 creator A5068050265 @default.
- W2072349276 date "2002-12-01" @default.
- W2072349276 modified "2023-10-09" @default.
- W2072349276 title "HIV mutagenesis and the evolution of antiretroviral drug resistance" @default.
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- W2072349276 doi "https://doi.org/10.1016/s1368-7646(02)00118-8" @default.
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