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• W2072350264 abstract "Aims: N-n-Butyl haloperidol iodide (F2) is a novel compound derived from haloperidol. In our previous work, F2 was found to be an L-type calcium channel blocker which played a protective role in rat heart ischemic–reperfusion injury in a dose-dependent manner. In the current study, we aimed to investigate the effects and some possible mechanisms of F2 on calcium transients in hypoxic/ischemic rat cardiac myocytes. Methods and Results: Calcium transients’ images of rat cardiac myocytes were recorded during simulated hypoxia, using a confocal calcium imaging system. The amplitude, rising time from 25% to 75% (RT25-75), decay time from 75% to 25% (DT75-25) of calcium transients, and resting [Ca2+]i were extracted from the images by self-coding programs. In this study, hypoxia produced a substantial increase in diastolic [Ca2+]i and reduced the amplitude of calcium transients. Both RT25-75 and DT75-25 of Ca2+ transients were significantly prolonged. And F2 could reduce the increase in resting [Ca2+]iand the prolongation of RT25-75 and DT75-25 of Ca2+ transients during hypoxia. F2 also inhibited the reduction in amplitude of calcium transients which was caused by 30-min hypoxia. The activity of SERCA2a (sarcoplasmic reticulum Ca2+-ATPase, determined by test kits) decreased after 30-min ischemia, and intravenous F2 in rats could ameliorate the decreased activity of SERCA2a. The inward and outward currents of NCX (recorded by whole-cell patch-clamp analysis) were reduced during 10-min hypoxia, and F2 further inhibited the outward currents of NCX during 10-min hypoxia. All these data of SERCA2a and NCX might be responsible for the changes in calcium transients during hypoxia. Conclusion: Our data suggest that F2 reduced changes in calcium transients that caused by hypoxia/ischemia, which was regarded to be a protective role in calcium homeostasis of ventricular myocytes, probably via changing the function of SERCA2a." @default.
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• W2072350264 date "2011-01-01" @default.
• W2072350264 modified "2023-10-18" @default.
• W2072350264 title "<i>N</i>-n-Butyl Haloperidol Iodide Preserves Cardiomyocyte Calcium Homeostasis during Hypoxia/Ischemia" @default.
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• W2072350264 doi "https://doi.org/10.1159/000329964" @default.
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