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• W2072355028 endingPage "7506" @default.
• W2072355028 startingPage "7495" @default.
• W2072355028 abstract "Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation. In a candidate screen, here we identify neurexin-1β lacking an insert at splice site 4 (−S4) as a ligand for LRRTM2. Neurexins bind LRRTM2 with a similar affinity but distinct code from the code for binding neuroligin-1 (the predominant form of neuroligin-1 at glutamate synapses, containing the B splice site insert). Whereas neuroligin-1 binds to neurexins 1, 2, and 3 β but not α variants, regardless of insert at splice site 4, LRRTM2 binds to neurexins 1, 2, and 3 α and β variants specifically lacking an insert at splice site 4. We further show that this binding code is conserved in LRRTM1, the family member linked to schizophrenia and handedness, and that the code is functional in a coculture hemisynapse formation assay. Mutagenesis of LRRTM2 to prevent binding to neurexins abolishes presynaptic inducing activity of LRRTM2. Remarkably, mutagenesis of neurexins shows that the binding face on neurexin-1β (−S4) is highly overlapping for the structurally distinct LRRTM2 and neuroligin-1 partners. Finally, we explore here the interplay of neuroligin-1 and LRRTM2 in synapse regulation. In neuron cultures, LRRTM2 is more potent than neuroligin-1 in promoting synaptic differentiation, and, most importantly, these two families of neurexin-binding partners cooperate in an additive or synergistic manner. Thus, we propose a synaptic code hypothesis suggesting that neurexins are master regulators of the cooperative activities of LRRTMs and neuroligins." @default.
• W2072355028 created "2016-06-24" @default.
• W2072355028 creator A5006347212 @default.
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• W2072355028 date "2010-06-02" @default.
• W2072355028 modified "2023-09-30" @default.
• W2072355028 title "LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development" @default.
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• W2072355028 doi "https://doi.org/10.1523/jneurosci.0470-10.2010" @default.
• W2072355028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2896269" @default.
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