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- W207235906 abstract "Publisher Summary This chapter discusses the synthesis of DNA-like polymers de novo or by reiterative replication. In the presence of DNA polymerase and certain deoxynucleoside triphosphates but in the absence of a template, novel polymers are synthesized after a lag period. The de novo synthesis of a macromolecular template occurs in the early part of the lag phase and these molecules are autocatalytically replicated. The chapter explains a model in which replication of the oligomer template is followed by slippage of the resulting helix by an AT dinucleotide pair; such replication and slippage would result in the continuous reiteration of the template and the synthesis of a large dAT copolymer. If reiterative events were to occur during in vivo replication, it would result in DNA modifications, which might be retained under some circumstances. If such reiterative events have occurred with any frequency in the evolution of DNA, they might be associated with distinctive mutational changes in the amino acid sequences of the proteins." @default.
- W207235906 created "2016-06-24" @default.
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- W207235906 date "1965-01-01" @default.
- W207235906 modified "2023-09-24" @default.
- W207235906 title "Synthesis of DNA-Like Polymers de novo or by Reiterative Replication" @default.
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- W207235906 doi "https://doi.org/10.1016/b978-1-4832-2734-4.50036-x" @default.
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