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- W2072362244 abstract "Drug transport from the nasal cavity to the brain has gained much interest in the last decade. In the present study, a model was developed to determine the uptake of drugs into the cerebrospinal fluid (CSF) after nasal delivery in rats. CSF samples were taken using a cisternal puncture method. In this method, a needle is advanced through the skin and muscles overlying the atlanto-occipital membrane into the cisterna magna, while the rat is fixed in a stereotaxic frame. This method appears to be superior over cannulation of the atlanto-occipital membrane for CSF sampling. The major advantages of the puncture method is the ability of serial and simultaneous CSF and blood sampling for over 2 h in the same rat. To obtain maximal drug absorption from the nasal cavity and uptake into CSF, different positions of the rat's head (upright-90°, supine-90°, supine-45° and supine-70° angles) were tested in nasal delivery studies using hydrocortisone (HC) as a model drug. Putting the rat in the supine-90° angle position increased the absorption of HC into plasma and CSF 2-fold compared to the upright-90° angle position. The supine-70° angle position did not change the HC plasma and CSF levels compared to the supine-90° angle position. However, the supine-70° angle position showed the fastest CSF sampling rate, enabling more accurate CSF sampling and therefore preferred for further studies. In conclusion, the cisternal puncture method using the supine-70° and 90° angle position is a suitable method to study drug transport from the nasal cavity into the CSF, with the ability of multiple CSF sampling." @default.
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- W2072362244 date "2002-04-01" @default.
- W2072362244 modified "2023-10-15" @default.
- W2072362244 title "Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity" @default.
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- W2072362244 doi "https://doi.org/10.1016/s0165-0270(02)00033-x" @default.
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