FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072364504> ?p ?o ?g. }

• W2072364504 endingPage "7677" @default.
• W2072364504 startingPage "7668" @default.
• W2072364504 abstract "VX-680 is a potent inhibitor of Aurora kinases that induces the accumulation of cells with > or =4N DNA content, followed by cell death. Here, we define the role of p53 and p21(Waf1/Cip1) in cell cycle perturbations following exposure to VX-680. Endoreduplication and apoptosis in response to VX-680 are limited in A549 and MCF-7 cells expressing wild-type p53, and markedly enhanced in cells lacking p53, including those engineered to express the HPV16-E6 oncoprotein or short interfering RNA pools targeting p53. In contrast, endoreduplication and apoptosis occur in the p53 wild-type cell lines, RKO and U2OS. The difference in response to VX-680 among these cell lines correlates with the timing of induction of p21(Waf1/Cip1) and its ability to inhibit cyclin E-cdk2 activity. In A549 cells, VX-680 induces the expression of p53 and p21(Waf1/Cip1) within 24 hours, with consequent inhibition of cyclin E-cdk2, and reduction of retinoblastoma protein phosphorylation, limiting endoreduplication. In RKO and U2OS cells, the induction of p21(Waf1/Cip1) is delayed and associated with higher residual cyclin E-cdk2 kinase activity and retinoblastoma protein phosphorylation, followed by progressive endoreduplication and apoptosis. Abrogation of p21(Waf1/Cip1) expression by short interfering RNA targeting in A549 cells results in a substantial increase in the degree of endoreduplication, whereas inducible expression of p21(Waf1/Cip1) in p53-negative NCI-H1299 cells inhibits VX-680-induced endoreduplication and cell death. These data suggest that the integrity of the p53-p21(Waf1/Cip1)-dependent postmitotic checkpoint governs the response to Aurora kinase inhibition. Although cells with intact checkpoint function arrest with 4N DNA content, those with compromised checkpoint function are more likely to undergo endoreduplication followed by eventual apoptosis." @default.
• W2072364504 created "2016-06-24" @default.
• W2072364504 creator A5030743286 @default.
• W2072364504 creator A5041443543 @default.
• W2072364504 creator A5044511167 @default.
• W2072364504 creator A5045197865 @default.
• W2072364504 creator A5045419282 @default.
• W2072364504 creator A5071763026 @default.
• W2072364504 date "2006-08-01" @default.
• W2072364504 modified "2023-10-12" @default.
• W2072364504 title "The Aurora Kinase Inhibitor VX-680 Induces Endoreduplication and Apoptosis Preferentially in Cells with Compromised p53-Dependent Postmitotic Checkpoint Function" @default.
• W2072364504 cites W1495729285 @default.
• W2072364504 cites W1556655356 @default.
• W2072364504 cites W1568426705 @default.
• W2072364504 cites W1657157395 @default.
• W2072364504 cites W1665081245 @default.
• W2072364504 cites W1980577287 @default.
• W2072364504 cites W1981073960 @default.
• W2072364504 cites W1989394815 @default.
• W2072364504 cites W2006240263 @default.
• W2072364504 cites W2016462887 @default.
• W2072364504 cites W2027516869 @default.
• W2072364504 cites W2033923680 @default.
• W2072364504 cites W2047533536 @default.
• W2072364504 cites W2060619702 @default.
• W2072364504 cites W2071156666 @default.
• W2072364504 cites W2071929035 @default.
• W2072364504 cites W2090930894 @default.
• W2072364504 cites W2095486134 @default.
• W2072364504 cites W2099682050 @default.
• W2072364504 cites W2105896701 @default.
• W2072364504 cites W2106942695 @default.
• W2072364504 cites W2112453291 @default.
• W2072364504 cites W2122230117 @default.
• W2072364504 cites W2128553601 @default.
• W2072364504 cites W2131833681 @default.
• W2072364504 cites W2136306650 @default.
• W2072364504 cites W2137429755 @default.
• W2072364504 cites W2139718226 @default.
• W2072364504 cites W2142583529 @default.
• W2072364504 cites W2164660906 @default.
• W2072364504 doi "https://doi.org/10.1158/0008-5472.can-05-3353" @default.
• W2072364504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16885368" @default.
• W2072364504 hasPublicationYear "2006" @default.
• W2072364504 type Work @default.
• W2072364504 sameAs 2072364504 @default.
• W2072364504 citedByCount "167" @default.
• W2072364504 countsByYear W20723645042012 @default.
• W2072364504 countsByYear W20723645042013 @default.
• W2072364504 countsByYear W20723645042014 @default.
• W2072364504 countsByYear W20723645042015 @default.
• W2072364504 countsByYear W20723645042016 @default.
• W2072364504 countsByYear W20723645042017 @default.
• W2072364504 countsByYear W20723645042018 @default.
• W2072364504 countsByYear W20723645042019 @default.
• W2072364504 countsByYear W20723645042020 @default.
• W2072364504 countsByYear W20723645042021 @default.
• W2072364504 countsByYear W20723645042022 @default.
• W2072364504 countsByYear W20723645042023 @default.
• W2072364504 crossrefType "journal-article" @default.
• W2072364504 hasAuthorship W2072364504A5030743286 @default.
• W2072364504 hasAuthorship W2072364504A5041443543 @default.
• W2072364504 hasAuthorship W2072364504A5044511167 @default.
• W2072364504 hasAuthorship W2072364504A5045197865 @default.
• W2072364504 hasAuthorship W2072364504A5045419282 @default.
• W2072364504 hasAuthorship W2072364504A5071763026 @default.
• W2072364504 hasBestOaLocation W20723645041 @default.
• W2072364504 hasConcept C105696609 @default.
• W2072364504 hasConcept C120504264 @default.
• W2072364504 hasConcept C124320809 @default.
• W2072364504 hasConcept C145226528 @default.
• W2072364504 hasConcept C153911025 @default.
• W2072364504 hasConcept C16438837 @default.
• W2072364504 hasConcept C184235292 @default.
• W2072364504 hasConcept C190283241 @default.
• W2072364504 hasConcept C2776062698 @default.
• W2072364504 hasConcept C2778437423 @default.
• W2072364504 hasConcept C29537977 @default.
• W2072364504 hasConcept C502942594 @default.
• W2072364504 hasConcept C55493867 @default.
• W2072364504 hasConcept C82495950 @default.
• W2072364504 hasConcept C86803240 @default.
• W2072364504 hasConcept C95444343 @default.
• W2072364504 hasConcept C97029542 @default.
• W2072364504 hasConceptScore W2072364504C105696609 @default.
• W2072364504 hasConceptScore W2072364504C120504264 @default.
• W2072364504 hasConceptScore W2072364504C124320809 @default.
• W2072364504 hasConceptScore W2072364504C145226528 @default.
• W2072364504 hasConceptScore W2072364504C153911025 @default.
• W2072364504 hasConceptScore W2072364504C16438837 @default.
• W2072364504 hasConceptScore W2072364504C184235292 @default.
• W2072364504 hasConceptScore W2072364504C190283241 @default.
• W2072364504 hasConceptScore W2072364504C2776062698 @default.
• W2072364504 hasConceptScore W2072364504C2778437423 @default.
• W2072364504 hasConceptScore W2072364504C29537977 @default.
• W2072364504 hasConceptScore W2072364504C502942594 @default.
• W2072364504 hasConceptScore W2072364504C55493867 @default.
• W2072364504 hasConceptScore W2072364504C82495950 @default.

• next