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- W2072374977 abstract "Correlation of the plasma levels of insulin-sensitizing, anti-inflammatory and anti-atherosclerotic adiponectin with HDL has been demonstrated. However, its relation to HDL-bound paraoxonase 1 (PON1) has not been clarified. The association of serum PON1 activity with findings of metabolic syndrome was investigated in three age and sex-matched groups: (1) non-diabetic overweight subjects with BMI 28–39.9 kg/m2 (n = 25); (2) non-diabetic obese subjects with BMI ≥ 40 kg/m2 (n = 25); and (3) healthy, normal-weight controls (n = 24). Of the parameters investigated, PON1 activity correlated positively with concentrations of HDL-C and adiponectin, and correlated negatively with BMI, waist circumference, systolic BP, levels of HbA1C, and insulin, HOMA-IR, and TBARS. The positive correlation between adiponectin and PON1 remained significant even after adjustments for age, gender, BMI, blood pressure, HOMA-IR, HDL-C, LDL-C, and lipid peroxidation.PON1 activity shows negative association with markers of metabolic syndrome. We demonstrate that adiponectin is an independent variable of serum PON1, which may contribute to the anti-atherosclerotic effect of adiponectin." @default.
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- W2072374977 date "2008-05-01" @default.
- W2072374977 modified "2023-10-18" @default.
- W2072374977 title "THE RELATIONSHIP BETWEEN THE OVERWEIGHT, OBESITY AND DYSLIPIDEMIA IN POLISH POPULATION AGED 20-74" @default.
- W2072374977 doi "https://doi.org/10.1016/s1567-5688(08)70977-2" @default.
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