FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072376324> ?p ?o ?g. }

• W2072376324 endingPage "233" @default.
• W2072376324 startingPage "225" @default.
• W2072376324 abstract "The function of most vertebrate genes remains unknown or uncertain. Insertional mutagenesis offers one approach to identify and understand the function of these genes. Transposons have been used successfully in lower organisms and plants for insertional mutagenesis, but until activation of the Sleeping Beauty (SB) transposon system, there was no indication of active DNA-based transposons in vertebrates. Investigator-driven insertional mutagenesis in vertebrates has relied on retroviral insertions or selection of low-frequency integration of naked DNA in ES cell lines. We have combined the highly active SB transposon with gene-trapping technology to demonstrate that transposon traps can be used for insertional mutagenesis screens in vertebrates. In our studies about one-fourth of the trap insertions appear to be in transcriptional units, a rate that is commensurate with random integration. We show that gene-traps coupled to a fluorescent protein reporter gene can be used to detect insertions into genes active in specific cells of living zebrafish embryos, supporting use of our transposon traps for high-throughput functional genomic screens in vertebrates." @default.
• W2072376324 created "2016-06-24" @default.
• W2072376324 creator A5010047567 @default.
• W2072376324 creator A5031428652 @default.
• W2072376324 creator A5032924224 @default.
• W2072376324 creator A5063827272 @default.
• W2072376324 date "2004-01-01" @default.
• W2072376324 modified "2023-09-23" @default.
• W2072376324 title "Transposon vectors for gene-trap insertional mutagenesis in vertebrates" @default.
• W2072376324 cites W1495724207 @default.
• W2072376324 cites W1586407854 @default.
• W2072376324 cites W1597871117 @default.
• W2072376324 cites W1797339176 @default.
• W2072376324 cites W1975880129 @default.
• W2072376324 cites W1976216196 @default.
• W2072376324 cites W1981829733 @default.
• W2072376324 cites W1989322815 @default.
• W2072376324 cites W1992386924 @default.
• W2072376324 cites W1993881548 @default.
• W2072376324 cites W1999336186 @default.
• W2072376324 cites W2001109802 @default.
• W2072376324 cites W2001519016 @default.
• W2072376324 cites W2009441114 @default.
• W2072376324 cites W2010104346 @default.
• W2072376324 cites W2034854683 @default.
• W2072376324 cites W2041266730 @default.
• W2072376324 cites W2043517829 @default.
• W2072376324 cites W2046354796 @default.
• W2072376324 cites W2047191657 @default.
• W2072376324 cites W2049246698 @default.
• W2072376324 cites W2055791890 @default.
• W2072376324 cites W2057173230 @default.
• W2072376324 cites W2069176827 @default.
• W2072376324 cites W2071629190 @default.
• W2072376324 cites W2080855924 @default.
• W2072376324 cites W2082103215 @default.
• W2072376324 cites W2085339391 @default.
• W2072376324 cites W2086689509 @default.
• W2072376324 cites W2090429649 @default.
• W2072376324 cites W2094167622 @default.
• W2072376324 cites W2096742260 @default.
• W2072376324 cites W2097632832 @default.
• W2072376324 cites W2103410475 @default.
• W2072376324 cites W2104630023 @default.
• W2072376324 cites W2105801710 @default.
• W2072376324 cites W2115372161 @default.
• W2072376324 cites W2116665001 @default.
• W2072376324 cites W2118937487 @default.
• W2072376324 cites W2121374699 @default.
• W2072376324 cites W2124292811 @default.
• W2072376324 cites W2127230663 @default.
• W2072376324 cites W2136324858 @default.
• W2072376324 cites W2148433018 @default.
• W2072376324 cites W2151464048 @default.
• W2072376324 cites W2152333152 @default.
• W2072376324 cites W2164618384 @default.
• W2072376324 cites W2168909179 @default.
• W2072376324 cites W2215627070 @default.
• W2072376324 cites W4230486389 @default.
• W2072376324 doi "https://doi.org/10.1002/gene.20049" @default.
• W2072376324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15286994" @default.
• W2072376324 hasPublicationYear "2004" @default.
• W2072376324 type Work @default.
• W2072376324 sameAs 2072376324 @default.
• W2072376324 citedByCount "61" @default.
• W2072376324 countsByYear W20723763242012 @default.
• W2072376324 countsByYear W20723763242013 @default.
• W2072376324 countsByYear W20723763242014 @default.
• W2072376324 countsByYear W20723763242015 @default.
• W2072376324 countsByYear W20723763242016 @default.
• W2072376324 countsByYear W20723763242017 @default.
• W2072376324 countsByYear W20723763242019 @default.
• W2072376324 countsByYear W20723763242021 @default.
• W2072376324 crossrefType "journal-article" @default.
• W2072376324 hasAuthorship W2072376324A5010047567 @default.
• W2072376324 hasAuthorship W2072376324A5031428652 @default.
• W2072376324 hasAuthorship W2072376324A5032924224 @default.
• W2072376324 hasAuthorship W2072376324A5063827272 @default.
• W2072376324 hasConcept C104317684 @default.
• W2072376324 hasConcept C107635520 @default.
• W2072376324 hasConcept C133288520 @default.
• W2072376324 hasConcept C134486438 @default.
• W2072376324 hasConcept C141231307 @default.
• W2072376324 hasConcept C143065580 @default.
• W2072376324 hasConcept C150194340 @default.
• W2072376324 hasConcept C160775987 @default.
• W2072376324 hasConcept C161733203 @default.
• W2072376324 hasConcept C16318435 @default.
• W2072376324 hasConcept C172510086 @default.
• W2072376324 hasConcept C2776878037 @default.
• W2072376324 hasConcept C28693550 @default.
• W2072376324 hasConcept C4918238 @default.
• W2072376324 hasConcept C54355233 @default.
• W2072376324 hasConcept C86803240 @default.
• W2072376324 hasConceptScore W2072376324C104317684 @default.
• W2072376324 hasConceptScore W2072376324C107635520 @default.
• W2072376324 hasConceptScore W2072376324C133288520 @default.
• W2072376324 hasConceptScore W2072376324C134486438 @default.

• next