FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072378043> ?p ?o ?g. }

• W2072378043 endingPage "360" @default.
• W2072378043 startingPage "353" @default.
• W2072378043 abstract "The renin-angiotensin system plays an important role in the maintenance of blood pressure homeostasis. The angiotensin-converting enzyme (ACE) converts angiotensin I into angiotensin II. Angiotensin II, which binds the angiotensin II type-1 receptor (AT1R), is a potent vasoconstrictor. On a pathophysiological basis, both ACE I/D and AT1R A1166C polymorphism lead to an enhanced activity of the angiotensin II-AT1R axis, thereby possibly contributing to circulatory disturbances. A mutually facilitatory effect may be presumed between the two polymorphisms. We examined whether this synergistic effect is involved in the evolution of different types of ischemic stroke. Genetic and clinical data on 308 consecutive patients with acutely developing ischemic stroke were analyzed. A total of 272 stroke and neuroimaging alteration-free subjects served as a control group. Univariate and logistic regression statistical approaches were used. The ACE D allele combined with the AT1R 1166C allele did not yield a risk of ischemic stroke. However, the co-occurrence of the homozygous ACE D/D and at least one AT1R 1166C allele was more frequent in the ischemic stroke group than in the control group (22.4 vs 11%, p<0.005, OR, 2.33; 95% CI, 1.46–3.7). After specific subgroup analysis, this synergistic association was even stronger for small-vessel ischemic stroke (OR, 3.44; 95% CI, 1.9–6.24; p<0.0005). Multivariate logistic regression analysis of the data confirmed this association (adjusted OR, 3.54, 95% CI, 1.88–7.16; p<0.0005). Our results demonstrate that ACE D/D and AT1R 1166C polymorphism were associated with the development of small-vessel ischemic stroke through a mutually facilitatory interplay between them. Genetic interactions might contribute to the altered functional network in renin-angiotensin system in vascular disorders." @default.
• W2072378043 created "2016-06-24" @default.
• W2072378043 creator A5003938743 @default.
• W2072378043 creator A5004199291 @default.
• W2072378043 creator A5004236995 @default.
• W2072378043 creator A5005314660 @default.
• W2072378043 creator A5022308048 @default.
• W2072378043 creator A5032037081 @default.
• W2072378043 creator A5036423597 @default.
• W2072378043 creator A5045563049 @default.
• W2072378043 creator A5052361003 @default.
• W2072378043 creator A5057342498 @default.
• W2072378043 creator A5083401224 @default.
• W2072378043 creator A5017153122 @default.
• W2072378043 date "2006-01-01" @default.
• W2072378043 modified "2023-09-27" @default.
• W2072378043 title "Coexistence of Angiotensin II Type-1 Receptor A1166C and Angiotensin-Converting Enzyme D/D Polymorphism Suggests Susceptibility for Small-Vessel-Associated Ischemic Stroke" @default.
• W2072378043 cites W1964982019 @default.
• W2072378043 cites W1974531338 @default.
• W2072378043 cites W1975096129 @default.
• W2072378043 cites W1988742278 @default.
• W2072378043 cites W1990442976 @default.
• W2072378043 cites W2002149579 @default.
• W2072378043 cites W2006352397 @default.
• W2072378043 cites W2011643486 @default.
• W2072378043 cites W2028117310 @default.
• W2072378043 cites W2029961872 @default.
• W2072378043 cites W2042603198 @default.
• W2072378043 cites W2043338070 @default.
• W2072378043 cites W2055851746 @default.
• W2072378043 cites W2069797303 @default.
• W2072378043 cites W2070592824 @default.
• W2072378043 cites W2080661995 @default.
• W2072378043 cites W2088230441 @default.
• W2072378043 cites W2091671824 @default.
• W2072378043 cites W2118094114 @default.
• W2072378043 cites W2122936122 @default.
• W2072378043 cites W2123728611 @default.
• W2072378043 cites W2137156703 @default.
• W2072378043 cites W2163216920 @default.
• W2072378043 cites W2170352583 @default.
• W2072378043 cites W2170942354 @default.
• W2072378043 doi "https://doi.org/10.1385/nmm:8:3:353" @default.
• W2072378043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7091324" @default.
• W2072378043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16775386" @default.
• W2072378043 hasPublicationYear "2006" @default.
• W2072378043 type Work @default.
• W2072378043 sameAs 2072378043 @default.
• W2072378043 citedByCount "24" @default.
• W2072378043 countsByYear W20723780432013 @default.
• W2072378043 countsByYear W20723780432014 @default.
• W2072378043 countsByYear W20723780432015 @default.
• W2072378043 countsByYear W20723780432019 @default.
• W2072378043 countsByYear W20723780432021 @default.
• W2072378043 crossrefType "journal-article" @default.
• W2072378043 hasAuthorship W2072378043A5003938743 @default.
• W2072378043 hasAuthorship W2072378043A5004199291 @default.
• W2072378043 hasAuthorship W2072378043A5004236995 @default.
• W2072378043 hasAuthorship W2072378043A5005314660 @default.
• W2072378043 hasAuthorship W2072378043A5017153122 @default.
• W2072378043 hasAuthorship W2072378043A5022308048 @default.
• W2072378043 hasAuthorship W2072378043A5032037081 @default.
• W2072378043 hasAuthorship W2072378043A5036423597 @default.
• W2072378043 hasAuthorship W2072378043A5045563049 @default.
• W2072378043 hasAuthorship W2072378043A5052361003 @default.
• W2072378043 hasAuthorship W2072378043A5057342498 @default.
• W2072378043 hasAuthorship W2072378043A5083401224 @default.
• W2072378043 hasBestOaLocation W20723780431 @default.
• W2072378043 hasConcept C104317684 @default.
• W2072378043 hasConcept C104849204 @default.
• W2072378043 hasConcept C123915805 @default.
• W2072378043 hasConcept C126322002 @default.
• W2072378043 hasConcept C127413603 @default.
• W2072378043 hasConcept C134018914 @default.
• W2072378043 hasConcept C151956035 @default.
• W2072378043 hasConcept C164705383 @default.
• W2072378043 hasConcept C170493617 @default.
• W2072378043 hasConcept C180754005 @default.
• W2072378043 hasConcept C198710026 @default.
• W2072378043 hasConcept C27016395 @default.
• W2072378043 hasConcept C2780645631 @default.
• W2072378043 hasConcept C2908929049 @default.
• W2072378043 hasConcept C54355233 @default.
• W2072378043 hasConcept C71924100 @default.
• W2072378043 hasConcept C78519656 @default.
• W2072378043 hasConcept C84393581 @default.
• W2072378043 hasConcept C86803240 @default.
• W2072378043 hasConceptScore W2072378043C104317684 @default.
• W2072378043 hasConceptScore W2072378043C104849204 @default.
• W2072378043 hasConceptScore W2072378043C123915805 @default.
• W2072378043 hasConceptScore W2072378043C126322002 @default.
• W2072378043 hasConceptScore W2072378043C127413603 @default.
• W2072378043 hasConceptScore W2072378043C134018914 @default.
• W2072378043 hasConceptScore W2072378043C151956035 @default.
• W2072378043 hasConceptScore W2072378043C164705383 @default.
• W2072378043 hasConceptScore W2072378043C170493617 @default.
• W2072378043 hasConceptScore W2072378043C180754005 @default.
• W2072378043 hasConceptScore W2072378043C198710026 @default.

• next