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• W2072379448 abstract "Summary We studied the production of cytokines by peripheral blood monocytes and T cells during the period of haematological recovery following intensive chemotherapy. Twelve adults with haematological malignancies received consolidation chemotherapy of complete remission. Monocytes and T cells were collected during the phase of recovery from intensive chemotherapy, and were incubated for 24 h in a culture medium with 10% FCS. Concentrations of cytokines in the culture supernatant were measured with an enzymelinked immunosorbent assay. During the recovery phase, concentrations of IL-6, G-CSF and IL-1β in the culture supernatant of the collected monocytes significantly exceeded those of the monocytes obtained from normal healthy subjects. Similarly, the concentrations of GM-CSF and IFN-γ in the supernatant of recovery phase T cells significantly exceeded those of normal T cells. Plasma levels of these cytokines were also elevated. These data suggest that the monocytes and T cells may be activated in vivo to produce haemopoietic cytolines during haematological recovery, and that, during haematological recovery, the monocytes and T cells may be actively involved in the induction of haematopoiesis following the myelosuppression induced by chemotherapy." @default.
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• W2072379448 date "1993-01-01" @default.
• W2072379448 modified "2023-09-29" @default.
• W2072379448 title "Cytokine production by peripheral blood monocytes and T cells during haemopoietic recovery after intensive chemotherapy" @default.
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• W2072379448 doi "https://doi.org/10.1111/j.1365-2141.1993.tb04625.x" @default.
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