FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072380888> ?p ?o ?g. }

• W2072380888 abstract "The ionic dependence of the [3H]-dopamine uptake was studied in transfected cells expressing the human neuronal transporter for dopamine (hDAT) or noradrenaline (hNET), and chimeric transporters resulting from the symmetrical exchange of the region from the NH2 terminal through the first two transmembrane domains (cassette I). Chimera A is formed by hDAT comprising cassette I from hNET, whereas chimera B corresponds to the reverse construct. The appearance or the intensity of a Cl(-)-independent component of transport was linked to the presence of the COOH terminal part of hNET in both monoclonal and polyclonal Ltk(-) cells (Cl(-) substituted by isethionate and NO3(-), respectively), and in transiently transfected COS-7 cells. Cassette I was also involved in the Cl(-)-dependence because the transport activity of polyclonal Ltk(-) cells expressing A was partly Cl(-)-independent and because Ltk(-) cells expressing transporters containing cassette I of hDAT displayed higher K(mCl)- values than cells expressing the reverse constructs. In monoclonal Ltk(-) cell lines, K(mNa)+ values and biphasic vs monophasic dependence upon Na(+) concentrations differentiate transporters containing cassette I of hNET from those containing cassette I of hDAT. In COS-7 cells, the exchange of cassette I produced a significant change in Hill number values. In Na(+)-dependence studies, exchange of the COOH terminal part significantly modified Hill number values in both Ltk(-) and COS-7 cells. Hill number values close to two were found for hNET and hDAT when sucrose was used as substitute for NaCl. The NH2 terminal part of the transporters bears some of the differences in the Na(+) and Cl(-)-dependence of the uptake that are observed between hDAT and hNET. Present results also support a role of the COOH terminal part in the ionic dependence." @default.
• W2072380888 created "2016-06-24" @default.
• W2072380888 creator A5006041048 @default.
• W2072380888 creator A5048696911 @default.
• W2072380888 creator A5069426565 @default.
• W2072380888 creator A5073288348 @default.
• W2072380888 creator A5077903137 @default.
• W2072380888 date "2001-06-01" @default.
• W2072380888 modified "2023-10-17" @default.
• W2072380888 title "Involvement of the NH2terminal domain of catecholamine transporters in the Na+and Cl−-dependence of a [3H]-dopamine uptake" @default.
• W2072380888 cites W1506737211 @default.
• W2072380888 cites W1514724839 @default.
• W2072380888 cites W1598676150 @default.
• W2072380888 cites W1815933758 @default.
• W2072380888 cites W1938622267 @default.
• W2072380888 cites W1974270221 @default.
• W2072380888 cites W1980253852 @default.
• W2072380888 cites W1992231666 @default.
• W2072380888 cites W2003266390 @default.
• W2072380888 cites W2014793858 @default.
• W2072380888 cites W2019594390 @default.
• W2072380888 cites W2047781376 @default.
• W2072380888 cites W2048341520 @default.
• W2072380888 cites W2055939533 @default.
• W2072380888 cites W2056132085 @default.
• W2072380888 cites W2060118024 @default.
• W2072380888 cites W2069049686 @default.
• W2072380888 cites W2074087813 @default.
• W2072380888 cites W2076548558 @default.
• W2072380888 cites W2078859596 @default.
• W2072380888 cites W2079204641 @default.
• W2072380888 cites W2083674889 @default.
• W2072380888 cites W2098835009 @default.
• W2072380888 cites W2129128665 @default.
• W2072380888 cites W2166640893 @default.
• W2072380888 doi "https://doi.org/10.1038/sj.bjp.0704097" @default.
• W2072380888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572801" @default.
• W2072380888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11375255" @default.
• W2072380888 hasPublicationYear "2001" @default.
• W2072380888 type Work @default.
• W2072380888 sameAs 2072380888 @default.
• W2072380888 citedByCount "5" @default.
• W2072380888 countsByYear W20723808882016 @default.
• W2072380888 crossrefType "journal-article" @default.
• W2072380888 hasAuthorship W2072380888A5006041048 @default.
• W2072380888 hasAuthorship W2072380888A5048696911 @default.
• W2072380888 hasAuthorship W2072380888A5069426565 @default.
• W2072380888 hasAuthorship W2072380888A5073288348 @default.
• W2072380888 hasAuthorship W2072380888A5077903137 @default.
• W2072380888 hasBestOaLocation W20723808883 @default.
• W2072380888 hasConcept C104317684 @default.
• W2072380888 hasConcept C12554922 @default.
• W2072380888 hasConcept C149011108 @default.
• W2072380888 hasConcept C170493617 @default.
• W2072380888 hasConcept C174510640 @default.
• W2072380888 hasConcept C185592680 @default.
• W2072380888 hasConcept C2776755682 @default.
• W2072380888 hasConcept C2909816965 @default.
• W2072380888 hasConcept C30278631 @default.
• W2072380888 hasConcept C44312359 @default.
• W2072380888 hasConcept C54009773 @default.
• W2072380888 hasConcept C55493867 @default.
• W2072380888 hasConcept C86803240 @default.
• W2072380888 hasConceptScore W2072380888C104317684 @default.
• W2072380888 hasConceptScore W2072380888C12554922 @default.
• W2072380888 hasConceptScore W2072380888C149011108 @default.
• W2072380888 hasConceptScore W2072380888C170493617 @default.
• W2072380888 hasConceptScore W2072380888C174510640 @default.
• W2072380888 hasConceptScore W2072380888C185592680 @default.
• W2072380888 hasConceptScore W2072380888C2776755682 @default.
• W2072380888 hasConceptScore W2072380888C2909816965 @default.
• W2072380888 hasConceptScore W2072380888C30278631 @default.
• W2072380888 hasConceptScore W2072380888C44312359 @default.
• W2072380888 hasConceptScore W2072380888C54009773 @default.
• W2072380888 hasConceptScore W2072380888C55493867 @default.
• W2072380888 hasConceptScore W2072380888C86803240 @default.
• W2072380888 hasLocation W20723808881 @default.
• W2072380888 hasLocation W20723808882 @default.
• W2072380888 hasLocation W20723808883 @default.
• W2072380888 hasLocation W20723808884 @default.
• W2072380888 hasLocation W20723808885 @default.
• W2072380888 hasOpenAccess W2072380888 @default.
• W2072380888 hasPrimaryLocation W20723808881 @default.
• W2072380888 hasRelatedWork W1996199040 @default.
• W2072380888 hasRelatedWork W2017635218 @default.
• W2072380888 hasRelatedWork W2056476032 @default.
• W2072380888 hasRelatedWork W2059372341 @default.
• W2072380888 hasRelatedWork W2062031160 @default.
• W2072380888 hasRelatedWork W2072380888 @default.
• W2072380888 hasRelatedWork W2090481633 @default.
• W2072380888 hasRelatedWork W2105612780 @default.
• W2072380888 hasRelatedWork W4206993470 @default.
• W2072380888 hasRelatedWork W86646785 @default.
• W2072380888 isParatext "false" @default.
• W2072380888 isRetracted "false" @default.
• W2072380888 magId "2072380888" @default.
• W2072380888 workType "article" @default.