Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072381888> ?p ?o ?g. }
- W2072381888 endingPage "4014" @default.
- W2072381888 startingPage "4004" @default.
- W2072381888 abstract "Drosophila larval neuromuscular junction (NMJ) is a well established preparation enabling quantitative analyses of synaptic physiology at identifiable synapses. Here, we report the first characterization of synaptic long-term depression (LTD) at the Drosophila NMJ. LTD can be reliably induced by specific patterns of tetanic stimulation, and the level of LTD depends on both stimulus frequency and Ca2+ concentration. We provide evidence that LTD is likely a result of presynaptic changes. Through screening of targeted mutants with defects in memory or signal transduction pathways, we found that LTD is strongly reduced in the akt mutants. This defect can be rescued by acutely induced expression of the normal akt transgene, suggesting that altered LTD is not attributable to developmental abnormalities and that Akt is critical for the induction of LTD. Our study also indicates that the molecular mechanisms of LTD are distinct from that of short-term synaptic plasticity, because akt mutants showed normal short-term facilitation and posttetanic potentiation, whereas LTD was unaffected in mutants that exhibit defective short-term synaptic plasticity, such as dunce and rutabaga. The characterization of LTD allows genetic analysis of the molecular mechanisms of long-term synaptic plasticity in Drosophila and provides an additional assay for studying functions of genes pertaining to synaptic and behavioral plasticity." @default.
- W2072381888 created "2016-06-24" @default.
- W2072381888 creator A5049412020 @default.
- W2072381888 creator A5050496181 @default.
- W2072381888 date "2006-04-12" @default.
- W2072381888 modified "2023-10-12" @default.
- W2072381888 title "Requirement of Akt to Mediate Long-Term Synaptic Depression in Drosophila" @default.
- W2072381888 cites W1510879979 @default.
- W2072381888 cites W1554441317 @default.
- W2072381888 cites W1590006710 @default.
- W2072381888 cites W1594236859 @default.
- W2072381888 cites W1615103583 @default.
- W2072381888 cites W1622746725 @default.
- W2072381888 cites W1912391091 @default.
- W2072381888 cites W1965303728 @default.
- W2072381888 cites W1972304279 @default.
- W2072381888 cites W1976344568 @default.
- W2072381888 cites W1979913537 @default.
- W2072381888 cites W1980655495 @default.
- W2072381888 cites W1989531657 @default.
- W2072381888 cites W1993506650 @default.
- W2072381888 cites W2006932987 @default.
- W2072381888 cites W2007786396 @default.
- W2072381888 cites W2008157904 @default.
- W2072381888 cites W2010909776 @default.
- W2072381888 cites W2012785062 @default.
- W2072381888 cites W2017506170 @default.
- W2072381888 cites W2019357185 @default.
- W2072381888 cites W2020931266 @default.
- W2072381888 cites W2024966724 @default.
- W2072381888 cites W2030445255 @default.
- W2072381888 cites W2031071883 @default.
- W2072381888 cites W2038561872 @default.
- W2072381888 cites W2042604124 @default.
- W2072381888 cites W2043867460 @default.
- W2072381888 cites W2048121649 @default.
- W2072381888 cites W2050524245 @default.
- W2072381888 cites W2052080357 @default.
- W2072381888 cites W2052600995 @default.
- W2072381888 cites W2055518516 @default.
- W2072381888 cites W2063362197 @default.
- W2072381888 cites W2076925699 @default.
- W2072381888 cites W2081834818 @default.
- W2072381888 cites W2083722773 @default.
- W2072381888 cites W2084133226 @default.
- W2072381888 cites W2084996914 @default.
- W2072381888 cites W2093607994 @default.
- W2072381888 cites W2098211983 @default.
- W2072381888 cites W2101741807 @default.
- W2072381888 cites W2102042356 @default.
- W2072381888 cites W2103731399 @default.
- W2072381888 cites W2103813921 @default.
- W2072381888 cites W2104119127 @default.
- W2072381888 cites W2110724392 @default.
- W2072381888 cites W2112927743 @default.
- W2072381888 cites W2117020954 @default.
- W2072381888 cites W2125858205 @default.
- W2072381888 cites W2129968788 @default.
- W2072381888 cites W2131856835 @default.
- W2072381888 cites W2135843883 @default.
- W2072381888 cites W2143034003 @default.
- W2072381888 cites W2146493911 @default.
- W2072381888 cites W2161155963 @default.
- W2072381888 cites W2163944330 @default.
- W2072381888 cites W2164339920 @default.
- W2072381888 cites W2173497794 @default.
- W2072381888 cites W2294592712 @default.
- W2072381888 cites W2329391383 @default.
- W2072381888 doi "https://doi.org/10.1523/jneurosci.3616-05.2006" @default.
- W2072381888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673878" @default.
- W2072381888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16611817" @default.
- W2072381888 hasPublicationYear "2006" @default.
- W2072381888 type Work @default.
- W2072381888 sameAs 2072381888 @default.
- W2072381888 citedByCount "38" @default.
- W2072381888 countsByYear W20723818882012 @default.
- W2072381888 countsByYear W20723818882013 @default.
- W2072381888 countsByYear W20723818882014 @default.
- W2072381888 countsByYear W20723818882015 @default.
- W2072381888 countsByYear W20723818882016 @default.
- W2072381888 countsByYear W20723818882017 @default.
- W2072381888 countsByYear W20723818882018 @default.
- W2072381888 countsByYear W20723818882021 @default.
- W2072381888 countsByYear W20723818882022 @default.
- W2072381888 crossrefType "journal-article" @default.
- W2072381888 hasAuthorship W2072381888A5049412020 @default.
- W2072381888 hasAuthorship W2072381888A5050496181 @default.
- W2072381888 hasBestOaLocation W20723818881 @default.
- W2072381888 hasConcept C104317684 @default.
- W2072381888 hasConcept C112592302 @default.
- W2072381888 hasConcept C125667969 @default.
- W2072381888 hasConcept C127445978 @default.
- W2072381888 hasConcept C160268369 @default.
- W2072381888 hasConcept C169760540 @default.
- W2072381888 hasConcept C170493617 @default.
- W2072381888 hasConcept C17077164 @default.
- W2072381888 hasConcept C194973443 @default.
- W2072381888 hasConcept C200170125 @default.