Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072387767> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2072387767 abstract "Antibody localization was analyzed following intraperitoneal (i.p.) or intravenous (i.v.) injection of the 125I-labelled anti-CEA-MAb I-38S1 in 44 nude rats, in order to evaluate the influence of tumour implantation site and the route of MAb administration. The animals were xenografted with a human colonic cancer (LS 174 T), either in the form of hepatic metastases, subcutaneous (s.c.) tumours or both. Tissue measurements, 4 days after MAb injection, showed better uptake for hepatic than for s.c. tumours, irrespective of the route of antibody administration. Antibody accumulation per g liver metastases was not size dependent for noduli weighing between 4 and 1,110 mg. MAb excretion evaluated in 20 animals and blood activity studied in 11 rats were equivalent 24-96 h following i.p. and i.v. injection. Dissimilar autoradiographic patterns were seen in hepatic metastases with predominantly peripherally located clusters following i.p. and more homogeneously distributed grains after i.v. MAb administration. The results indicate that tumour implantation site has a quantitative, and the route of administration at least a qualitative impact on the tumour accretion of anti-CEA MAb I-38S1 in the present xenograft model." @default.
- W2072387767 created "2016-06-24" @default.
- W2072387767 creator A5023269056 @default.
- W2072387767 creator A5034734088 @default.
- W2072387767 creator A5040034652 @default.
- W2072387767 creator A5057158252 @default.
- W2072387767 creator A5057827537 @default.
- W2072387767 creator A5089890461 @default.
- W2072387767 date "1993-01-01" @default.
- W2072387767 modified "2023-09-23" @default.
- W2072387767 title "Radioimmunolocalization of Hepatic Metastases and Subcutaneous Xenografts from a Human Colonic Cancer: In the Nude Rat: Aspects of Tumour Implantation Site and Mode of Antibody Administration" @default.
- W2072387767 cites W1973544892 @default.
- W2072387767 cites W1976376655 @default.
- W2072387767 cites W1999058050 @default.
- W2072387767 cites W2000093975 @default.
- W2072387767 cites W2017495035 @default.
- W2072387767 cites W2019911229 @default.
- W2072387767 cites W2020488897 @default.
- W2072387767 cites W2032493223 @default.
- W2072387767 cites W2033785962 @default.
- W2072387767 cites W2059524272 @default.
- W2072387767 cites W2061219378 @default.
- W2072387767 cites W2089120635 @default.
- W2072387767 cites W2105036645 @default.
- W2072387767 cites W2161649581 @default.
- W2072387767 cites W2165873235 @default.
- W2072387767 cites W2257988791 @default.
- W2072387767 cites W2469935172 @default.
- W2072387767 doi "https://doi.org/10.3109/02841869309096150" @default.
- W2072387767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8305240" @default.
- W2072387767 hasPublicationYear "1993" @default.
- W2072387767 type Work @default.
- W2072387767 sameAs 2072387767 @default.
- W2072387767 citedByCount "6" @default.
- W2072387767 crossrefType "journal-article" @default.
- W2072387767 hasAuthorship W2072387767A5023269056 @default.
- W2072387767 hasAuthorship W2072387767A5034734088 @default.
- W2072387767 hasAuthorship W2072387767A5040034652 @default.
- W2072387767 hasAuthorship W2072387767A5057158252 @default.
- W2072387767 hasAuthorship W2072387767A5057827537 @default.
- W2072387767 hasAuthorship W2072387767A5089890461 @default.
- W2072387767 hasConcept C121608353 @default.
- W2072387767 hasConcept C126322002 @default.
- W2072387767 hasConcept C142724271 @default.
- W2072387767 hasConcept C150903083 @default.
- W2072387767 hasConcept C159654299 @default.
- W2072387767 hasConcept C203014093 @default.
- W2072387767 hasConcept C207001950 @default.
- W2072387767 hasConcept C25938499 @default.
- W2072387767 hasConcept C2776093070 @default.
- W2072387767 hasConcept C2776390293 @default.
- W2072387767 hasConcept C2779013556 @default.
- W2072387767 hasConcept C542903549 @default.
- W2072387767 hasConcept C71924100 @default.
- W2072387767 hasConcept C86803240 @default.
- W2072387767 hasConceptScore W2072387767C121608353 @default.
- W2072387767 hasConceptScore W2072387767C126322002 @default.
- W2072387767 hasConceptScore W2072387767C142724271 @default.
- W2072387767 hasConceptScore W2072387767C150903083 @default.
- W2072387767 hasConceptScore W2072387767C159654299 @default.
- W2072387767 hasConceptScore W2072387767C203014093 @default.
- W2072387767 hasConceptScore W2072387767C207001950 @default.
- W2072387767 hasConceptScore W2072387767C25938499 @default.
- W2072387767 hasConceptScore W2072387767C2776093070 @default.
- W2072387767 hasConceptScore W2072387767C2776390293 @default.
- W2072387767 hasConceptScore W2072387767C2779013556 @default.
- W2072387767 hasConceptScore W2072387767C542903549 @default.
- W2072387767 hasConceptScore W2072387767C71924100 @default.
- W2072387767 hasConceptScore W2072387767C86803240 @default.
- W2072387767 hasLocation W20723877671 @default.
- W2072387767 hasLocation W20723877672 @default.
- W2072387767 hasOpenAccess W2072387767 @default.
- W2072387767 hasPrimaryLocation W20723877671 @default.
- W2072387767 hasRelatedWork W169857821 @default.
- W2072387767 hasRelatedWork W1769403823 @default.
- W2072387767 hasRelatedWork W1819842632 @default.
- W2072387767 hasRelatedWork W1970355216 @default.
- W2072387767 hasRelatedWork W1973774944 @default.
- W2072387767 hasRelatedWork W1978475328 @default.
- W2072387767 hasRelatedWork W1985628011 @default.
- W2072387767 hasRelatedWork W1990734308 @default.
- W2072387767 hasRelatedWork W2025566232 @default.
- W2072387767 hasRelatedWork W2259520070 @default.
- W2072387767 isParatext "false" @default.
- W2072387767 isRetracted "false" @default.
- W2072387767 magId "2072387767" @default.
- W2072387767 workType "article" @default.