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- W2072388481 abstract "The renal handling of cyclosporine was studied in ischemically damaged kidneys in New Zealand White rabbits and nonischemic control animals. CsA, 25 mg/ kg/day, was administered intravenously for 10 days starting with the day of operation. Blood CsA (B CsA) was higher in the ischemie group compared with the controls (median: 285 μg/L, range 95–785 μg/L vs. 170 μg/L, range 110–185 μg/L, P = 0.05) on day 1 after operation. B CsA dropped rapidly to a level equivalent to the controls by day 4 (median: 105 μg/L, range 60–280 μg/L vs. 195 μg/L, range 70–215 μg/L, P = NS). Median CsA clearance (C CsA) as a percentage of creatinine clearance (C Cr) was some ten-fold greater in the ischemie animals (6.32%, range 2.93–18.41% vs. 0.55%, range 0.13–0.78%, P < 0.001) on day 1. The ratio gradually declined, approaching the value in controls by day 10 (0.86%, range 0.24–7.21% vs. 0.23%, range 0.16–0.73%, P = 0.05). The data suggest that renal impairment has an important effect on CsA blood levels. In the clinical situation this may be of particular importance during both oliguria and the recovery from acute tubular necrosis." @default.
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- W2072388481 date "1990-03-01" @default.
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- W2072388481 title "THE EFFECT OF RENAL ISCHEMIA ON CYCLOSPORINE CLEARANCE IN RABBITS" @default.
- W2072388481 doi "https://doi.org/10.1097/00007890-199003000-00004" @default.
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