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• W2072389679 abstract "The ubiquitin-activating enzyme E1 catalyzes the first step in ubiquitin conjugation. We have cloned and sequenced the cDNA for human E1. This clone predicts a protein of 110,450 Da. Cys-194 lies within a region of identity to active-site Cys-88 of the ubiquitin carrier protein E2, suggesting a potential role for this region in enzymatic function of this protein. In addition, Cys-454 lies within a region of identity to the thiol ester consensus sequence of several proteins involved in thioester formation. Tissue distribution reveals a single 3.5-kilobase E1 message ubiquitous among tissues and cell lines." @default.
• W2072389679 created "2016-06-24" @default.
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• W2072389679 date "1991-01-01" @default.
• W2072389679 modified "2023-10-01" @default.
• W2072389679 title "Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1." @default.
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• W2072389679 doi "https://doi.org/10.1073/pnas.88.1.258" @default.
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