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- W2072397070 endingPage "1516" @default.
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- W2072397070 abstract "• Introduction • Activation of caspases - Activation of apoptotic caspases - Activation of inflammatory caspases - Interleukins, their activation by caspases and their role in inflammation • Small molecule inhibitors of caspase activity and activation - Modification of caspase activation - Synthetic molecules as inhibitors of caspase activity • Role of caspases in disease - Caspases as targets in conditions associated with increased levels of apoptosis - Neurodegenerative disease - Ischaemia - Ischaemia/reperfusion injury – implications in transplant injury - Inflammatory diseases - Role of caspases in sepsis – mediators of apoptosis and inflammation - Role of caspase-1 and -12 in sepsis - Role of apoptotic caspases in sepsis • Challenges facing the development of caspase therapeutics • Role of caspases in other aspects of cell death • Role of caspases in non-apoptotic and non-inflammatory processes - Role of caspases in differentiation and cell fusion - Role of caspases in cell proliferation • The future of caspase therapeutics Abstract The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed." @default.
- W2072397070 created "2016-06-24" @default.
- W2072397070 creator A5003954107 @default.
- W2072397070 creator A5060128809 @default.
- W2072397070 date "2008-09-01" @default.
- W2072397070 modified "2023-10-01" @default.
- W2072397070 title "Caspases as therapeutic targets" @default.
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