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• W2072397582 abstract "In an attempt to generate compounds with superior bioactivity and reduced toxicity, a series of derivatives of deoxypodophyllotoxin were synthesized by reacting 4'-demethyl-4-deoxypodophyllotoxin with substituted piperazines or their amino acid amides. The cytotoxic activity of these compounds against three human cancer cell lines was evaluated. We found that p-nitrophenylpiperazine substitution (Compound 8b) led to an increase in the potency of the compound. Compound 8b exhibited the most potent cytotoxicity against A-549, HeLa and SiHa cells (IC(50) values were 0.102, 0.180 and 0.0195 μM, respectively). In addition, flow cytometric analysis showed that 8b induced cell cycle arrest in the G1 phase accompanied by apoptosis in A-549 cells." @default.
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• W2072397582 date "2011-09-01" @default.
• W2072397582 modified "2023-09-23" @default.
• W2072397582 title "Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents" @default.
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• W2072397582 doi "https://doi.org/10.1016/j.ejmech.2011.06.004" @default.
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