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• W2072397761 abstract "The prospective therapeutic, propionyl-l-carnitine, was labelled in the N-methyl position with the positronemitter, carbon-11 (t12 = 20.4 min), with a view to studying its pharmacokinetics in humans using PET. Labelling was achieved by methylating nor-propionyl-l-carnitine hydrochloride with no-carrier-added [11C]iodomethane (produced from cyclotron-produced [11C]carbon dioxide) in ethanol in the presence of 1,2,2,6,6-pentamethylpiperidine. HPLC of the reaction mixture on a strong cation exchange column provided high purity [N-methyl-11C]propionyl-l-carnitine in 62% radiochemical yield (decay-corrected from [11C]iodomethane), ready for intravenous administration within 35 min from the end of radionuclide production. [N-methyl-11C]Propionyl-l-carnitine, given intravenously to rats, cleared rapidly from plasma. A slow uptake of radioactivity into myocardium and striated muscle was observed. In plasma, unchanged tracer represented 84% of the radioactivity at 2.5 min and 2.5% of the radioactivity at 60 min. In heart, unchanged tracer represented 18% of radioactivity at 2.5 min and 2.4% at 15 min. The remainder of radioactivity detected in plasma and heart was identified as [N-methyl-11C]l-carnitine and [N-methyl-11C]acetyl-l-carnitine." @default.
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• W2072397761 date "1995-08-01" @default.
• W2072397761 modified "2023-09-24" @default.
• W2072397761 title "Propionyl-l-carnitine: Labelling in the N-methyl position with carbon-11 and pharmacokinetic studies in rats" @default.
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• W2072397761 doi "https://doi.org/10.1016/0969-8051(95)00010-u" @default.
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