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• W2072401586 abstract "Latent HIV-1 (human immunodeficiency virus-1) provirus is unaffected by current AIDS (acquired immunodeficiency syndrome) therapies. We show here that chaetocin, an SUV39H1 histone methyltransferase inhibitor, causes 25-fold induction of latent HIV-1 expression, while producing minimal toxicity and without causing T cell activation. Induction is associated with loss of histone H3 lysine 9 (H3K9) trimethylation at the long terminal repeat (LTR) promoter, and a corresponding increase in H3K9 acetylation. The effect of chaetocin is amplified synergistically in combination with histone deacetylase (HDAC) inhibitors. These results indicate that chaetocin may provide a therapy to purge cells of latent HIV-1, possibly in combination with other chromatin remodeling drugs." @default.
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• W2072401586 date "2011-10-19" @default.
• W2072401586 modified "2023-10-16" @default.
• W2072401586 title "The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response" @default.
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• W2072401586 doi "https://doi.org/10.1016/j.febslet.2011.10.018" @default.
• W2072401586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22020221" @default.
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