FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072404469> ?p ?o ?g. }

• W2072404469 endingPage "151" @default.
• W2072404469 startingPage "145" @default.
• W2072404469 abstract "Mere15 is a novel antitumor polypeptide purified from Meretrix meretrix Linn. (Veneridae). Previous studies have shown that the polypeptide induced cell death via intrinsic mitochondrial pathway.In the present study, the effects of Mere15 on cell adhesion, migration, invasion, as well as secretion and expression of matrix metalloproteinases (MMPs) were studied in human lung adenocarcinoma A549 cells.The effect of Mere15 on cell adhesion, migration and invasion were studied by cell adhesion and transwell assay. The expression of MMPs was determined by gelatin zymography and RT-PCR analysis.The ability of cell adhesion was decreased by 86.74% at the concentration of 12.0 μg/mL of Mere15. And the migration and invasion of A549 cells were decreased with the inhibition ratio of, 69.22 and 53.84% when treated with 15.0 μg/mL of Mere15. Further study also revealed that treatment of the cancer cells with Mere15 (15.0 μg/mL), the secretion of MMP-2 and MMP-9 were down-regulated with the inhibition ratio of 72.00 and 93.24% and the inhibition rate of mRNA expression of MMP-2 and MMP-9 was 57.54 and 91.22%, respectively.The study demonstrates that Mere15 inhibits tumor growth via both pro-apoptotic and antimetastasis pathways, and the polypeptide has potential to be developed as a multi-target therapeutic agent for the treatment of human lung cancer." @default.
• W2072404469 created "2016-06-24" @default.
• W2072404469 creator A5019056174 @default.
• W2072404469 creator A5019421112 @default.
• W2072404469 creator A5028125849 @default.
• W2072404469 creator A5044166963 @default.
• W2072404469 creator A5048502490 @default.
• W2072404469 creator A5051026327 @default.
• W2072404469 creator A5069603686 @default.
• W2072404469 creator A5074822731 @default.
• W2072404469 creator A5090366405 @default.
• W2072404469 date "2012-11-08" @default.
• W2072404469 modified "2023-09-27" @default.
• W2072404469 title "Mere15, a novel polypeptide from<i>Meretrix meretrix</i>, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs" @default.
• W2072404469 cites W1967334719 @default.
• W2072404469 cites W1970897882 @default.
• W2072404469 cites W1992194315 @default.
• W2072404469 cites W2011518988 @default.
• W2072404469 cites W2020830322 @default.
• W2072404469 cites W2033778431 @default.
• W2072404469 cites W2040273792 @default.
• W2072404469 cites W2060167247 @default.
• W2072404469 cites W2065448275 @default.
• W2072404469 cites W2088032801 @default.
• W2072404469 cites W2111447964 @default.
• W2072404469 cites W2114918609 @default.
• W2072404469 cites W2128955496 @default.
• W2072404469 cites W2136419903 @default.
• W2072404469 cites W2147392160 @default.
• W2072404469 cites W2329728544 @default.
• W2072404469 doi "https://doi.org/10.3109/13880209.2012.715169" @default.
• W2072404469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23134156" @default.
• W2072404469 hasPublicationYear "2012" @default.
• W2072404469 type Work @default.
• W2072404469 sameAs 2072404469 @default.
• W2072404469 citedByCount "11" @default.
• W2072404469 countsByYear W20724044692014 @default.
• W2072404469 countsByYear W20724044692017 @default.
• W2072404469 countsByYear W20724044692018 @default.
• W2072404469 countsByYear W20724044692019 @default.
• W2072404469 countsByYear W20724044692020 @default.
• W2072404469 countsByYear W20724044692021 @default.
• W2072404469 countsByYear W20724044692022 @default.
• W2072404469 crossrefType "journal-article" @default.
• W2072404469 hasAuthorship W2072404469A5019056174 @default.
• W2072404469 hasAuthorship W2072404469A5019421112 @default.
• W2072404469 hasAuthorship W2072404469A5028125849 @default.
• W2072404469 hasAuthorship W2072404469A5044166963 @default.
• W2072404469 hasAuthorship W2072404469A5048502490 @default.
• W2072404469 hasAuthorship W2072404469A5051026327 @default.
• W2072404469 hasAuthorship W2072404469A5069603686 @default.
• W2072404469 hasAuthorship W2072404469A5074822731 @default.
• W2072404469 hasAuthorship W2072404469A5090366405 @default.
• W2072404469 hasBestOaLocation W20724044691 @default.
• W2072404469 hasConcept C109523444 @default.
• W2072404469 hasConcept C121608353 @default.
• W2072404469 hasConcept C137738243 @default.
• W2072404469 hasConcept C1491633281 @default.
• W2072404469 hasConcept C153911025 @default.
• W2072404469 hasConcept C177430391 @default.
• W2072404469 hasConcept C178790620 @default.
• W2072404469 hasConcept C185592680 @default.
• W2072404469 hasConcept C190283241 @default.
• W2072404469 hasConcept C49039625 @default.
• W2072404469 hasConcept C502942594 @default.
• W2072404469 hasConcept C54355233 @default.
• W2072404469 hasConcept C55493867 @default.
• W2072404469 hasConcept C62112901 @default.
• W2072404469 hasConcept C81729549 @default.
• W2072404469 hasConcept C84416704 @default.
• W2072404469 hasConcept C85789140 @default.
• W2072404469 hasConcept C86803240 @default.
• W2072404469 hasConcept C96232424 @default.
• W2072404469 hasConceptScore W2072404469C109523444 @default.
• W2072404469 hasConceptScore W2072404469C121608353 @default.
• W2072404469 hasConceptScore W2072404469C137738243 @default.
• W2072404469 hasConceptScore W2072404469C1491633281 @default.
• W2072404469 hasConceptScore W2072404469C153911025 @default.
• W2072404469 hasConceptScore W2072404469C177430391 @default.
• W2072404469 hasConceptScore W2072404469C178790620 @default.
• W2072404469 hasConceptScore W2072404469C185592680 @default.
• W2072404469 hasConceptScore W2072404469C190283241 @default.
• W2072404469 hasConceptScore W2072404469C49039625 @default.
• W2072404469 hasConceptScore W2072404469C502942594 @default.
• W2072404469 hasConceptScore W2072404469C54355233 @default.
• W2072404469 hasConceptScore W2072404469C55493867 @default.
• W2072404469 hasConceptScore W2072404469C62112901 @default.
• W2072404469 hasConceptScore W2072404469C81729549 @default.
• W2072404469 hasConceptScore W2072404469C84416704 @default.
• W2072404469 hasConceptScore W2072404469C85789140 @default.
• W2072404469 hasConceptScore W2072404469C86803240 @default.
• W2072404469 hasConceptScore W2072404469C96232424 @default.
• W2072404469 hasIssue "2" @default.
• W2072404469 hasLocation W20724044691 @default.
• W2072404469 hasLocation W20724044692 @default.
• W2072404469 hasOpenAccess W2072404469 @default.
• W2072404469 hasPrimaryLocation W20724044691 @default.
• W2072404469 hasRelatedWork W1515058559 @default.

• next