FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072409852> ?p ?o ?g. }

• W2072409852 endingPage "2496" @default.
• W2072409852 startingPage "2490" @default.
• W2072409852 abstract "BACKGROUND. Chronic hepatitis C can result in fatty changes in the liver. Previous studies have suggested that hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus (HCV) infection. The authors sought to determine whether hepatic steatosis is associated with hepatocellular carcinoma (HCC) in a cohort of patients with hepatitis C-related cirrhosis. METHODS. The authors retrospectively identified 94 consecutive patients with hepatitis C cirrhosis who underwent liver transplantation from 1992 to 2005 and had pathology available for review. Of these, 32 had evidence of HCC, and 62 had no HCC on explant histology. All explant specimens were graded again for steatosis by a single, blinded pathologist. Steatosis, age, sex, body mass index, HCV RNA, HCV genotype, Model for End-Stage Liver Disease (MELD) score, chronic alcohol use, and diabetes were examined in univariate and multivariate analyses for association with HCC. RESULTS. In total, 69% of patients in the HCC group and 50% of patients in the control group had evidence of steatosis (1+) on histology. Odds ratios for the development of HCC for each grade of steatosis compared with grade 0 were as follows: grade 1 (1.61 [0.6–4.3]), grade 2 (3.68 [1.1–12.8]), and grade 3 or 4 (8.02 [0.6–108.3]) (P = .03 for the trend). In univariate analysis, there was a significant association between increasing steatosis grade (P = .03), older age (56 years vs 49 years; P < .02), higher aspartate aminotransferase (122.5 U/L vs 91.5 U/L; P = .005), higher alanine aminotransferase (95.8 U/L vs 57.2 U/L; P = .002), higher alpha-fetoprotein (113.5 ng/mL vs 17.8 ng/mL; P < .001), lower median HCV RNA (239,000 IU/mL vs 496,500 IU/mL; P = .02), higher biologic MELD score (21.8 vs 20.3; P = .03), and risk of HCC. In multivariate analysis, age (P = .02), AFP (P = .007), and steatosis (P = .045) were significantly associated with HCC. CONCLUSIONS. In patients with HCV-related cirrhosis, the presence of hepatic steatosis is independently associated with the development of hepatocellular carcinoma. These findings suggest that steatosis poses an additional risk for HCC and that increased vigilance should be practiced in surveillance of persons with both HCV and steatosis. Cancer 2007. © 2007 American Cancer Society." @default.
• W2072409852 created "2016-06-24" @default.
• W2072409852 creator A5020069661 @default.
• W2072409852 creator A5049800814 @default.
• W2072409852 creator A5053259508 @default.
• W2072409852 creator A5059142660 @default.
• W2072409852 date "2007-06-15" @default.
• W2072409852 modified "2023-10-07" @default.
• W2072409852 title "Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis" @default.
• W2072409852 cites W1534360145 @default.
• W2072409852 cites W1980780644 @default.
• W2072409852 cites W1981900811 @default.
• W2072409852 cites W1991401793 @default.
• W2072409852 cites W1997819680 @default.
• W2072409852 cites W2000679354 @default.
• W2072409852 cites W2001671445 @default.
• W2072409852 cites W2001869632 @default.
• W2072409852 cites W2005346484 @default.
• W2072409852 cites W2016129823 @default.
• W2072409852 cites W2027014617 @default.
• W2072409852 cites W2029834382 @default.
• W2072409852 cites W2031888288 @default.
• W2072409852 cites W2039857559 @default.
• W2072409852 cites W2041194988 @default.
• W2072409852 cites W2046719161 @default.
• W2072409852 cites W2047919099 @default.
• W2072409852 cites W2052754205 @default.
• W2072409852 cites W2053978445 @default.
• W2072409852 cites W2057211436 @default.
• W2072409852 cites W2064590565 @default.
• W2072409852 cites W2071875898 @default.
• W2072409852 cites W2079872150 @default.
• W2072409852 cites W2082185635 @default.
• W2072409852 cites W2082509181 @default.
• W2072409852 cites W2082842671 @default.
• W2072409852 cites W2096487185 @default.
• W2072409852 cites W2097094525 @default.
• W2072409852 cites W2118285452 @default.
• W2072409852 cites W2119371081 @default.
• W2072409852 cites W2123511080 @default.
• W2072409852 cites W2124261717 @default.
• W2072409852 cites W2138004489 @default.
• W2072409852 cites W2141662760 @default.
• W2072409852 cites W2152954739 @default.
• W2072409852 cites W2154239359 @default.
• W2072409852 cites W2163991469 @default.
• W2072409852 cites W2164118055 @default.
• W2072409852 cites W2321119966 @default.
• W2072409852 doi "https://doi.org/10.1002/cncr.22701" @default.
• W2072409852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17487861" @default.
• W2072409852 hasPublicationYear "2007" @default.
• W2072409852 type Work @default.
• W2072409852 sameAs 2072409852 @default.
• W2072409852 citedByCount "173" @default.
• W2072409852 countsByYear W20724098522012 @default.
• W2072409852 countsByYear W20724098522013 @default.
• W2072409852 countsByYear W20724098522014 @default.
• W2072409852 countsByYear W20724098522015 @default.
• W2072409852 countsByYear W20724098522016 @default.
• W2072409852 countsByYear W20724098522017 @default.
• W2072409852 countsByYear W20724098522018 @default.
• W2072409852 countsByYear W20724098522019 @default.
• W2072409852 countsByYear W20724098522020 @default.
• W2072409852 countsByYear W20724098522021 @default.
• W2072409852 countsByYear W20724098522022 @default.
• W2072409852 countsByYear W20724098522023 @default.
• W2072409852 crossrefType "journal-article" @default.
• W2072409852 hasAuthorship W2072409852A5020069661 @default.
• W2072409852 hasAuthorship W2072409852A5049800814 @default.
• W2072409852 hasAuthorship W2072409852A5053259508 @default.
• W2072409852 hasAuthorship W2072409852A5059142660 @default.
• W2072409852 hasBestOaLocation W20724098521 @default.
• W2072409852 hasConcept C126322002 @default.
• W2072409852 hasConcept C144301174 @default.
• W2072409852 hasConcept C203014093 @default.
• W2072409852 hasConcept C2522874641 @default.
• W2072409852 hasConcept C2776175330 @default.
• W2072409852 hasConcept C2776408679 @default.
• W2072409852 hasConcept C2776455275 @default.
• W2072409852 hasConcept C2777075537 @default.
• W2072409852 hasConcept C2777214474 @default.
• W2072409852 hasConcept C2778019345 @default.
• W2072409852 hasConcept C2778772119 @default.
• W2072409852 hasConcept C2779134260 @default.
• W2072409852 hasConcept C2779609443 @default.
• W2072409852 hasConcept C2911091166 @default.
• W2072409852 hasConcept C38180746 @default.
• W2072409852 hasConcept C71924100 @default.
• W2072409852 hasConcept C90924648 @default.
• W2072409852 hasConceptScore W2072409852C126322002 @default.
• W2072409852 hasConceptScore W2072409852C144301174 @default.
• W2072409852 hasConceptScore W2072409852C203014093 @default.
• W2072409852 hasConceptScore W2072409852C2522874641 @default.
• W2072409852 hasConceptScore W2072409852C2776175330 @default.
• W2072409852 hasConceptScore W2072409852C2776408679 @default.
• W2072409852 hasConceptScore W2072409852C2776455275 @default.
• W2072409852 hasConceptScore W2072409852C2777075537 @default.
• W2072409852 hasConceptScore W2072409852C2777214474 @default.

• next