Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072413561> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2072413561 abstract "Identification of biomarkers for breast cancer metastasis is a well studied problem. Recently, several large-scale studies used gene expression data to identify markers related to metastatic process. However, it was shown that these gene expression based markers often have low reproducibility across different data sets, for a number of reasons. These include small sample sizes compared to the number of genes, gene expression variations between individuals that do not contribute to the metastasis process, and the limitation for microarray technology being unable to detect changes beyond transcriptional level. Here a graph-theoretical approach based on the topology of protein-protein interaction (PPI) networks is proposed for biomarker discovery. The idea is to identify a set of genes that give connectivity to differentially expressed (DE) genes in a PPI network, based on the key observation that biomarkers may provide functional linkage to DE genes in PPI networks. Our approach is applied to two breast cancer microarray datasets for biomarker discovery. Those biomarkers have a significant number of known cancer susceptibility genes among them and are significantly enriched in biological processes and pathways that are involved in carcinogenic process. Furthermore, markers selected by our method have a higher stability across the two datasets than in the previous studies. Therefore, the approach described in this study is a new way to identify novel biomarkers for cancer metastasis and can potentially improve the understanding of carcinogenesis dynamics." @default.
- W2072413561 created "2016-06-24" @default.
- W2072413561 creator A5011524797 @default.
- W2072413561 creator A5071308796 @default.
- W2072413561 date "2011-12-01" @default.
- W2072413561 modified "2023-09-26" @default.
- W2072413561 title "Identification of biomarkers in breast cancer metastasis by integrating protein-protein interaction network and gene expression data" @default.
- W2072413561 cites W2020541351 @default.
- W2072413561 cites W2082150701 @default.
- W2072413561 cites W2110160785 @default.
- W2072413561 cites W2117937654 @default.
- W2072413561 cites W2128985829 @default.
- W2072413561 cites W2150414518 @default.
- W2072413561 cites W2151768167 @default.
- W2072413561 cites W2154947819 @default.
- W2072413561 cites W2157795344 @default.
- W2072413561 cites W2158217645 @default.
- W2072413561 cites W2160450758 @default.
- W2072413561 cites W2163563958 @default.
- W2072413561 cites W2167119716 @default.
- W2072413561 cites W2167913971 @default.
- W2072413561 cites W2168264491 @default.
- W2072413561 doi "https://doi.org/10.1109/gensips.2011.6169443" @default.
- W2072413561 hasPublicationYear "2011" @default.
- W2072413561 type Work @default.
- W2072413561 sameAs 2072413561 @default.
- W2072413561 citedByCount "3" @default.
- W2072413561 countsByYear W20724135612012 @default.
- W2072413561 countsByYear W20724135612015 @default.
- W2072413561 countsByYear W20724135612017 @default.
- W2072413561 crossrefType "proceedings-article" @default.
- W2072413561 hasAuthorship W2072413561A5011524797 @default.
- W2072413561 hasAuthorship W2072413561A5071308796 @default.
- W2072413561 hasConcept C104317684 @default.
- W2072413561 hasConcept C116834253 @default.
- W2072413561 hasConcept C121608353 @default.
- W2072413561 hasConcept C124535831 @default.
- W2072413561 hasConcept C150194340 @default.
- W2072413561 hasConcept C186836561 @default.
- W2072413561 hasConcept C2777002142 @default.
- W2072413561 hasConcept C2779013556 @default.
- W2072413561 hasConcept C2781197716 @default.
- W2072413561 hasConcept C46111723 @default.
- W2072413561 hasConcept C530470458 @default.
- W2072413561 hasConcept C54355233 @default.
- W2072413561 hasConcept C555283112 @default.
- W2072413561 hasConcept C59822182 @default.
- W2072413561 hasConcept C60644358 @default.
- W2072413561 hasConcept C67339327 @default.
- W2072413561 hasConcept C70721500 @default.
- W2072413561 hasConcept C8415881 @default.
- W2072413561 hasConcept C86803240 @default.
- W2072413561 hasConceptScore W2072413561C104317684 @default.
- W2072413561 hasConceptScore W2072413561C116834253 @default.
- W2072413561 hasConceptScore W2072413561C121608353 @default.
- W2072413561 hasConceptScore W2072413561C124535831 @default.
- W2072413561 hasConceptScore W2072413561C150194340 @default.
- W2072413561 hasConceptScore W2072413561C186836561 @default.
- W2072413561 hasConceptScore W2072413561C2777002142 @default.
- W2072413561 hasConceptScore W2072413561C2779013556 @default.
- W2072413561 hasConceptScore W2072413561C2781197716 @default.
- W2072413561 hasConceptScore W2072413561C46111723 @default.
- W2072413561 hasConceptScore W2072413561C530470458 @default.
- W2072413561 hasConceptScore W2072413561C54355233 @default.
- W2072413561 hasConceptScore W2072413561C555283112 @default.
- W2072413561 hasConceptScore W2072413561C59822182 @default.
- W2072413561 hasConceptScore W2072413561C60644358 @default.
- W2072413561 hasConceptScore W2072413561C67339327 @default.
- W2072413561 hasConceptScore W2072413561C70721500 @default.
- W2072413561 hasConceptScore W2072413561C8415881 @default.
- W2072413561 hasConceptScore W2072413561C86803240 @default.
- W2072413561 hasLocation W20724135611 @default.
- W2072413561 hasOpenAccess W2072413561 @default.
- W2072413561 hasPrimaryLocation W20724135611 @default.
- W2072413561 hasRelatedWork W1593344907 @default.
- W2072413561 hasRelatedWork W192377586 @default.
- W2072413561 hasRelatedWork W1984240153 @default.
- W2072413561 hasRelatedWork W1993209020 @default.
- W2072413561 hasRelatedWork W2091926526 @default.
- W2072413561 hasRelatedWork W2108933430 @default.
- W2072413561 hasRelatedWork W2140118692 @default.
- W2072413561 hasRelatedWork W2145029433 @default.
- W2072413561 hasRelatedWork W2154947819 @default.
- W2072413561 hasRelatedWork W2157732154 @default.
- W2072413561 hasRelatedWork W2235675875 @default.
- W2072413561 hasRelatedWork W2322148544 @default.
- W2072413561 hasRelatedWork W2773456614 @default.
- W2072413561 hasRelatedWork W2922896129 @default.
- W2072413561 hasRelatedWork W2972707277 @default.
- W2072413561 hasRelatedWork W3004801523 @default.
- W2072413561 hasRelatedWork W3005660249 @default.
- W2072413561 hasRelatedWork W3130888151 @default.
- W2072413561 hasRelatedWork W3183245147 @default.
- W2072413561 hasRelatedWork W943454091 @default.
- W2072413561 isParatext "false" @default.
- W2072413561 isRetracted "false" @default.
- W2072413561 magId "2072413561" @default.
- W2072413561 workType "article" @default.