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- W2072417974 abstract "A goal of evolutionary developmental biology is to understand the genetic changes, and subsequent changes in developmental programs, which underlie body plan evolution. In PNAS, Guerreiro et al. (1) characterize genetic variation that likely contributes to the homogenization of the vertebral column in snakes. The authors identify a polymorphism in the regulatory region of the Myogenic factor 5 (Myf5) gene, which in turn indirectly regulates rib growth. Guerreiro et al. elegantly show that the snake-specific variation in the Myf5 enhancer blocks interaction with a rib-repressing Hox protein, but preserves interaction with a second, rib-promoting Hox protein. This variation is expected to permit “lumbar”-level ribs, which are blocked in most tetrapods, to develop in snakes." @default.
- W2072417974 created "2016-06-24" @default.
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- W2072417974 date "2013-06-07" @default.
- W2072417974 modified "2023-10-17" @default.
- W2072417974 title "<i>cis</i> -regulatory change associated with snake body plan evolution" @default.
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- W2072417974 doi "https://doi.org/10.1073/pnas.1307778110" @default.
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