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- W2072425103 abstract "Klaiber et al. (1979) performed a 12-week, double-blind, placebo-controlled study of very high doses of estrogen in a group of 40 preand postmenopausal women with severe and resistant depression. A moderate antidepressant effect was seen in the estrogen-treated group compared with the controls. In an open study, the effects of a 4-week treatment with 0.06 rag/day of ethinyl estradiol was investigated in 10 premenopausal and 10 postmenopausal women with endogenous depression (Holsboer et al. 1983). A decrease in the Hamilton depression score of at least 12 points was achieved in seven postmenopausal and four premenopausal patients. Prange (1972) compared 150 mg of imipramine plus ethinyl estradiol to imipramine alone during 3 weeks of antidepressant treatment. The two treatments were equally effective after 3 weeks, but increased toxicity was seen in the combination group, and it was suggested that estrogen may affect antidepressant blood levels. Oppenheim (1984) reported a patient with resistant depression in whom the addition of conjugated estrogen to an antidepressant drug induced the condition of rapid mood cycling, which is a direct complication of various agents with antidepressant activity." @default.
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- W2072425103 date "1985-05-01" @default.
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- W2072425103 title "Lack of efficacy of estrogen supplementation to imipramine in resistant female depressives" @default.
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- W2072425103 doi "https://doi.org/10.1016/0006-3223(85)90031-9" @default.
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