FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072439648> ?p ?o ?g. }

• W2072439648 endingPage "550" @default.
• W2072439648 startingPage "541" @default.
• W2072439648 abstract "Secreted frizzled-related protein-5 (sFRP-5) has been identified as 1 of the secreted antagonists that bind Wnt protein. However, the functional significance of sFRP-5 in renal cell cancer (RCC) has not been reported. We hypothesized that sFRP-5 may be epigenetically downregulated through DNA methylation and histone modification and function as a tumor suppressor gene in RCC. Using tissue microarray and real-time RT-PCR, we found that sFRP-5 was significantly downregulated in kidney cancer tissues and cell lines, respectively. DNA bisulfite sequencing of the sFRP-5 promoter region in RCC cell lines showed it to be densely methylated, whereas there was few promoter methylation in normal kidney. The sFRP-5 expression was restored and the acetylation of H3 and H4 histones associated with the sFRP-5 promoter region were significantly increased after treatment with demethylation agent (5-Aza-dc) and histone deacetylase inhibitor (TSA). When RCC cells were transfected with the sFRP-5 gene, significant inhibition of anchorage independent colony formation and cell invasion were observed compared to controls. The sFRP-5 transfection also significantly induced apoptosis in RCC cells. In conclusion, this is the first report documenting that the sFRP-5 is downregulated by promoter methylation and histone acetylation and functions as a tumor suppressor gene by inducing apoptosis in RCC cells." @default.
• W2072439648 created "2016-06-24" @default.
• W2072439648 creator A5000406250 @default.
• W2072439648 creator A5012638832 @default.
• W2072439648 creator A5019633750 @default.
• W2072439648 creator A5021530000 @default.
• W2072439648 creator A5027943200 @default.
• W2072439648 creator A5038105097 @default.
• W2072439648 creator A5044574879 @default.
• W2072439648 creator A5062821742 @default.
• W2072439648 creator A5064773091 @default.
• W2072439648 creator A5071471877 @default.
• W2072439648 creator A5085150253 @default.
• W2072439648 date "2010-11-27" @default.
• W2072439648 modified "2023-10-17" @default.
• W2072439648 title "Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancer" @default.
• W2072439648 cites W1967137553 @default.
• W2072439648 cites W1968366612 @default.
• W2072439648 cites W1970184785 @default.
• W2072439648 cites W1973267581 @default.
• W2072439648 cites W1975306683 @default.
• W2072439648 cites W1975341256 @default.
• W2072439648 cites W1975853332 @default.
• W2072439648 cites W1980141592 @default.
• W2072439648 cites W1983924164 @default.
• W2072439648 cites W1984009107 @default.
• W2072439648 cites W1984374221 @default.
• W2072439648 cites W1989215255 @default.
• W2072439648 cites W1995382565 @default.
• W2072439648 cites W2026598269 @default.
• W2072439648 cites W2036264366 @default.
• W2072439648 cites W2038131544 @default.
• W2072439648 cites W2040723131 @default.
• W2072439648 cites W2057096351 @default.
• W2072439648 cites W2064945386 @default.
• W2072439648 cites W2066031443 @default.
• W2072439648 cites W2070244957 @default.
• W2072439648 cites W2079819294 @default.
• W2072439648 cites W2090704433 @default.
• W2072439648 cites W2096217287 @default.
• W2072439648 cites W2102728571 @default.
• W2072439648 cites W2117809535 @default.
• W2072439648 cites W2137146162 @default.
• W2072439648 cites W2137517357 @default.
• W2072439648 cites W2139122477 @default.
• W2072439648 cites W2149199597 @default.
• W2072439648 cites W2150000725 @default.
• W2072439648 cites W2154590990 @default.
• W2072439648 cites W2156559492 @default.
• W2072439648 cites W2158770560 @default.
• W2072439648 cites W2167638513 @default.
• W2072439648 cites W2169000920 @default.
• W2072439648 cites W2332316926 @default.
• W2072439648 cites W2342351330 @default.
• W2072439648 cites W4243323059 @default.
• W2072439648 cites W4376848386 @default.
• W2072439648 doi "https://doi.org/10.1002/ijc.25357" @default.
• W2072439648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3940353" @default.
• W2072439648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20340127" @default.
• W2072439648 hasPublicationYear "2010" @default.
• W2072439648 type Work @default.
• W2072439648 sameAs 2072439648 @default.
• W2072439648 citedByCount "44" @default.
• W2072439648 countsByYear W20724396482012 @default.
• W2072439648 countsByYear W20724396482013 @default.
• W2072439648 countsByYear W20724396482014 @default.
• W2072439648 countsByYear W20724396482015 @default.
• W2072439648 countsByYear W20724396482016 @default.
• W2072439648 countsByYear W20724396482017 @default.
• W2072439648 countsByYear W20724396482018 @default.
• W2072439648 countsByYear W20724396482019 @default.
• W2072439648 countsByYear W20724396482020 @default.
• W2072439648 countsByYear W20724396482021 @default.
• W2072439648 countsByYear W20724396482023 @default.
• W2072439648 crossrefType "journal-article" @default.
• W2072439648 hasAuthorship W2072439648A5000406250 @default.
• W2072439648 hasAuthorship W2072439648A5012638832 @default.
• W2072439648 hasAuthorship W2072439648A5019633750 @default.
• W2072439648 hasAuthorship W2072439648A5021530000 @default.
• W2072439648 hasAuthorship W2072439648A5027943200 @default.
• W2072439648 hasAuthorship W2072439648A5038105097 @default.
• W2072439648 hasAuthorship W2072439648A5044574879 @default.
• W2072439648 hasAuthorship W2072439648A5062821742 @default.
• W2072439648 hasAuthorship W2072439648A5064773091 @default.
• W2072439648 hasAuthorship W2072439648A5071471877 @default.
• W2072439648 hasAuthorship W2072439648A5085150253 @default.
• W2072439648 hasBestOaLocation W20724396481 @default.
• W2072439648 hasConcept C104317684 @default.
• W2072439648 hasConcept C114691636 @default.
• W2072439648 hasConcept C121608353 @default.
• W2072439648 hasConcept C137620995 @default.
• W2072439648 hasConcept C150194340 @default.
• W2072439648 hasConcept C153911025 @default.
• W2072439648 hasConcept C190727270 @default.
• W2072439648 hasConcept C2777865847 @default.
• W2072439648 hasConcept C2778264664 @default.
• W2072439648 hasConcept C2778305200 @default.
• W2072439648 hasConcept C41091548 @default.

• next