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- W2072451720 endingPage "706" @default.
- W2072451720 startingPage "675" @default.
- W2072451720 abstract "A large body of evidence indicates that the withdrawal from high doses of psychostimulant drugs in humans induces a transient syndrome, with symptoms that appear isomorphic to those of major depressive disorder. Pharmacological treatment strategies for psychostimulant withdrawal in humans have focused mainly on compounds with antidepressant properties. Animal models of psychostimulant withdrawal have been shown to demonstrate a wide range of deficits, including changes in homeostatic, affective and cognitive behaviors, as well as numerous physiological changes. Many of these behavioral and physiological sequelae parallel specific symptoms of major depressive disorder, and have been reversed by treatment with antidepressant drugs. These combined findings provide strong support for the use of psychostimulant withdrawal as an inducing condition in animal models of depression. In the current review we propound that the psychostimulant withdrawal model displays high levels of predictive and construct validity. Recent progress and limitations in the development of this model, as well as future directions for research, are evaluated and discussed." @default.
- W2072451720 created "2016-06-24" @default.
- W2072451720 creator A5073852920 @default.
- W2072451720 creator A5089103560 @default.
- W2072451720 date "2005-01-01" @default.
- W2072451720 modified "2023-09-27" @default.
- W2072451720 title "Psychostimulant withdrawal as an inducing condition in animal models of depression" @default.
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