FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072453335> ?p ?o ?g. }

• W2072453335 endingPage "13218" @default.
• W2072453335 startingPage "13216" @default.
• W2072453335 abstract "Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and similar channels constitutes a significant challenge in chemical neurobiology. In the present work, we use a stereochemical probe to evaluate a proposed pin-into-hydrophobic socket mechanism for the αVal46 side chain of the nAChR. Utilizing nonsense suppression methodology we incorporated isoleucine (Ile), O-methyl threonine (Omt) and threonine (Thr) as well as their side chain epimers (the allo counterparts). Surprisingly, our results indicate that only the pro-S methyl group of the αVal46 side chain is sensitive to changes in hydrophobicity, consistent with the precise geometrical requirements of the pin-into-socket mechanism." @default.
• W2072453335 created "2016-06-24" @default.
• W2072453335 creator A5002660163 @default.
• W2072453335 creator A5024286952 @default.
• W2072453335 creator A5081474546 @default.
• W2072453335 date "2008-09-10" @default.
• W2072453335 modified "2023-10-18" @default.
• W2072453335 title "A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor" @default.
• W2072453335 cites W1591881216 @default.
• W2072453335 cites W1971422019 @default.
• W2072453335 cites W1992799801 @default.
• W2072453335 cites W2005843451 @default.
• W2072453335 cites W2032233949 @default.
• W2072453335 cites W2032493626 @default.
• W2072453335 cites W2039840333 @default.
• W2072453335 cites W2042485714 @default.
• W2072453335 cites W2050352579 @default.
• W2072453335 cites W2056305953 @default.
• W2072453335 cites W2059566159 @default.
• W2072453335 cites W2070107288 @default.
• W2072453335 cites W2072769231 @default.
• W2072453335 cites W2074890710 @default.
• W2072453335 cites W2101887667 @default.
• W2072453335 cites W2106948759 @default.
• W2072453335 cites W2121222517 @default.
• W2072453335 cites W2143014450 @default.
• W2072453335 cites W2166674578 @default.
• W2072453335 doi "https://doi.org/10.1021/ja8015457" @default.
• W2072453335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18781739" @default.
• W2072453335 hasPublicationYear "2008" @default.
• W2072453335 type Work @default.
• W2072453335 sameAs 2072453335 @default.
• W2072453335 citedByCount "11" @default.
• W2072453335 countsByYear W20724533352012 @default.
• W2072453335 countsByYear W20724533352013 @default.
• W2072453335 countsByYear W20724533352014 @default.
• W2072453335 countsByYear W20724533352015 @default.
• W2072453335 countsByYear W20724533352019 @default.
• W2072453335 countsByYear W20724533352021 @default.
• W2072453335 countsByYear W20724533352023 @default.
• W2072453335 crossrefType "journal-article" @default.
• W2072453335 hasAuthorship W2072453335A5002660163 @default.
• W2072453335 hasAuthorship W2072453335A5024286952 @default.
• W2072453335 hasAuthorship W2072453335A5081474546 @default.
• W2072453335 hasConcept C111472728 @default.
• W2072453335 hasConcept C11960822 @default.
• W2072453335 hasConcept C12554922 @default.
• W2072453335 hasConcept C138885662 @default.
• W2072453335 hasConcept C170493617 @default.
• W2072453335 hasConcept C178790620 @default.
• W2072453335 hasConcept C185592680 @default.
• W2072453335 hasConcept C188987157 @default.
• W2072453335 hasConcept C194544171 @default.
• W2072453335 hasConcept C204921945 @default.
• W2072453335 hasConcept C2775880066 @default.
• W2072453335 hasConcept C2775910092 @default.
• W2072453335 hasConcept C2776414213 @default.
• W2072453335 hasConcept C2779570518 @default.
• W2072453335 hasConcept C521977710 @default.
• W2072453335 hasConcept C55493867 @default.
• W2072453335 hasConcept C71240020 @default.
• W2072453335 hasConcept C71924100 @default.
• W2072453335 hasConcept C80161118 @default.
• W2072453335 hasConcept C86803240 @default.
• W2072453335 hasConcept C89611455 @default.
• W2072453335 hasConcept C98274493 @default.
• W2072453335 hasConceptScore W2072453335C111472728 @default.
• W2072453335 hasConceptScore W2072453335C11960822 @default.
• W2072453335 hasConceptScore W2072453335C12554922 @default.
• W2072453335 hasConceptScore W2072453335C138885662 @default.
• W2072453335 hasConceptScore W2072453335C170493617 @default.
• W2072453335 hasConceptScore W2072453335C178790620 @default.
• W2072453335 hasConceptScore W2072453335C185592680 @default.
• W2072453335 hasConceptScore W2072453335C188987157 @default.
• W2072453335 hasConceptScore W2072453335C194544171 @default.
• W2072453335 hasConceptScore W2072453335C204921945 @default.
• W2072453335 hasConceptScore W2072453335C2775880066 @default.
• W2072453335 hasConceptScore W2072453335C2775910092 @default.
• W2072453335 hasConceptScore W2072453335C2776414213 @default.
• W2072453335 hasConceptScore W2072453335C2779570518 @default.
• W2072453335 hasConceptScore W2072453335C521977710 @default.
• W2072453335 hasConceptScore W2072453335C55493867 @default.
• W2072453335 hasConceptScore W2072453335C71240020 @default.
• W2072453335 hasConceptScore W2072453335C71924100 @default.
• W2072453335 hasConceptScore W2072453335C80161118 @default.
• W2072453335 hasConceptScore W2072453335C86803240 @default.
• W2072453335 hasConceptScore W2072453335C89611455 @default.
• W2072453335 hasConceptScore W2072453335C98274493 @default.
• W2072453335 hasIssue "40" @default.
• W2072453335 hasLocation W20724533351 @default.
• W2072453335 hasLocation W20724533352 @default.
• W2072453335 hasOpenAccess W2072453335 @default.
• W2072453335 hasPrimaryLocation W20724533351 @default.
• W2072453335 hasRelatedWork W1983677705 @default.
• W2072453335 hasRelatedWork W2012174837 @default.
• W2072453335 hasRelatedWork W2028920824 @default.
• W2072453335 hasRelatedWork W2033865162 @default.
• W2072453335 hasRelatedWork W2037471264 @default.

• next