Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072471280> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2072471280 endingPage "269" @default.
- W2072471280 startingPage "264" @default.
- W2072471280 abstract "A considerable number of growth factors, cytokines, and adhesion molecules are implicated in the development of atherosclerotic lesions. These molecules interact in a complex network influencing the evolution of several processes, such as lipid metabolism, cellular proliferation and tissue repair. The aim of this study was to evaluate the expression of the growth factors PDGF-A, and TGFb, and the adhesion molecule VCAM-1 in the sequential steps of experimental atherogenesis.Forty-two New Zealand white male rabbits were divided into 4 groups. The group A rabbits (n = 8) received normal diet and served as control animals. The remaining groups were fed with a diet enriched with 1% cholesterol and 6% corn oil. The rabbits of group B (n = 9) were sacrificed 1 month after the beginning of the study, of group C (n = 15) after 2 months and of group D (n = 10) after 3 months. In tissue sections of the aortic arch the antibodies of the prementioned factors were detected immunohistochemically.In group A only TGFb and PDGF-A were detectable. In lesions of the first month PDGF-A expression was high but declined towards the third month. VCAM-1 expression was getting more intense up to the second month and subsided thereafter. TGFb expression intensified towards the third month. Changes in the expression of these factors were statistically significant.PDGF-A, responsible for the uncontrollable growth of smooth muscle cells, and VCAM-1, regulating monocyte recruitment in the intima, acts mainly during the early stages of atherogenesis. TGFb, one of the main factors controlling the formation of connective tissue matrix, has a gradually increasing expression towards the third month contributing probably to the fibrous plaque formation." @default.
- W2072471280 created "2016-06-24" @default.
- W2072471280 creator A5005862923 @default.
- W2072471280 creator A5046184511 @default.
- W2072471280 creator A5047130243 @default.
- W2072471280 creator A5049823742 @default.
- W2072471280 creator A5064466570 @default.
- W2072471280 creator A5086606757 @default.
- W2072471280 creator A5087702087 @default.
- W2072471280 date "2001-01-01" @default.
- W2072471280 modified "2023-10-03" @default.
- W2072471280 title "Expression of PDGF-A, TGFb and VCAM-1 during the Developmental Stages of Experimental Atherosclerosis" @default.
- W2072471280 cites W2088471254 @default.
- W2072471280 cites W2137570167 @default.
- W2072471280 cites W2335187016 @default.
- W2072471280 doi "https://doi.org/10.1159/000049716" @default.
- W2072471280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11684832" @default.
- W2072471280 hasPublicationYear "2001" @default.
- W2072471280 type Work @default.
- W2072471280 sameAs 2072471280 @default.
- W2072471280 citedByCount "28" @default.
- W2072471280 countsByYear W20724712802014 @default.
- W2072471280 countsByYear W20724712802015 @default.
- W2072471280 countsByYear W20724712802019 @default.
- W2072471280 countsByYear W20724712802021 @default.
- W2072471280 countsByYear W20724712802023 @default.
- W2072471280 crossrefType "journal-article" @default.
- W2072471280 hasAuthorship W2072471280A5005862923 @default.
- W2072471280 hasAuthorship W2072471280A5046184511 @default.
- W2072471280 hasAuthorship W2072471280A5047130243 @default.
- W2072471280 hasAuthorship W2072471280A5049823742 @default.
- W2072471280 hasAuthorship W2072471280A5064466570 @default.
- W2072471280 hasAuthorship W2072471280A5086606757 @default.
- W2072471280 hasAuthorship W2072471280A5087702087 @default.
- W2072471280 hasConcept C126322002 @default.
- W2072471280 hasConcept C134018914 @default.
- W2072471280 hasConcept C142724271 @default.
- W2072471280 hasConcept C16224149 @default.
- W2072471280 hasConcept C16685009 @default.
- W2072471280 hasConcept C170493617 @default.
- W2072471280 hasConcept C180361614 @default.
- W2072471280 hasConcept C185946421 @default.
- W2072471280 hasConcept C203014093 @default.
- W2072471280 hasConcept C2775960820 @default.
- W2072471280 hasConcept C2776985958 @default.
- W2072471280 hasConcept C2779980429 @default.
- W2072471280 hasConcept C2781285907 @default.
- W2072471280 hasConcept C2781294074 @default.
- W2072471280 hasConcept C71924100 @default.
- W2072471280 hasConcept C86803240 @default.
- W2072471280 hasConceptScore W2072471280C126322002 @default.
- W2072471280 hasConceptScore W2072471280C134018914 @default.
- W2072471280 hasConceptScore W2072471280C142724271 @default.
- W2072471280 hasConceptScore W2072471280C16224149 @default.
- W2072471280 hasConceptScore W2072471280C16685009 @default.
- W2072471280 hasConceptScore W2072471280C170493617 @default.
- W2072471280 hasConceptScore W2072471280C180361614 @default.
- W2072471280 hasConceptScore W2072471280C185946421 @default.
- W2072471280 hasConceptScore W2072471280C203014093 @default.
- W2072471280 hasConceptScore W2072471280C2775960820 @default.
- W2072471280 hasConceptScore W2072471280C2776985958 @default.
- W2072471280 hasConceptScore W2072471280C2779980429 @default.
- W2072471280 hasConceptScore W2072471280C2781285907 @default.
- W2072471280 hasConceptScore W2072471280C2781294074 @default.
- W2072471280 hasConceptScore W2072471280C71924100 @default.
- W2072471280 hasConceptScore W2072471280C86803240 @default.
- W2072471280 hasIssue "4" @default.
- W2072471280 hasLocation W20724712801 @default.
- W2072471280 hasLocation W20724712802 @default.
- W2072471280 hasOpenAccess W2072471280 @default.
- W2072471280 hasPrimaryLocation W20724712801 @default.
- W2072471280 hasRelatedWork W2038000824 @default.
- W2072471280 hasRelatedWork W2072471280 @default.
- W2072471280 hasRelatedWork W2078751457 @default.
- W2072471280 hasRelatedWork W2087090518 @default.
- W2072471280 hasRelatedWork W2098742882 @default.
- W2072471280 hasRelatedWork W2118947223 @default.
- W2072471280 hasRelatedWork W2130332764 @default.
- W2072471280 hasRelatedWork W4236502113 @default.
- W2072471280 hasRelatedWork W4237074184 @default.
- W2072471280 hasRelatedWork W4249598711 @default.
- W2072471280 hasVolume "33" @default.
- W2072471280 isParatext "false" @default.
- W2072471280 isRetracted "false" @default.
- W2072471280 magId "2072471280" @default.
- W2072471280 workType "article" @default.