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• W2072476547 abstract "Extreme variation in leg length is both disabling and distressing. Seldom does one encounter this situation as the result of x-irradiation. The inhibiting and destructive effects of roentgen rays on epiphyseal cartilage have been demonstrated in the animal by a number of investigators. During the first decade of the twentieth century Perthes, Recamier and Tribondeau, Forsterling and Krukenberg subjected numerous small animals to irradiation, demonstrating that exposure to x-rays caused more or less retardation in the growth of bones and other structures. In general, it was determined by these investigators that the degree and duration of growth inhibition were governed by the age of the animal and the dosage. In late years, detailed animal studies, well controlled, have been conducted by Barr and his associates (1, 7), Bisgard and Hunt (2), Brooks and Hillstrom (3), Regen and Wilkins (6). Their observations demonstrate without question that bone growth in the young can be retarded or stopped by a sufficient dosage of x-ray. The microscopic picture of the epiphysis following irradiation is that of chondrocyte degeneration — diminished numbers of primitive chondrocytes, a disruption of the orderly arrangement of cartilage columns and abnormal foci of calcification away from the normal metaphyseal location. No significant evidence of growth stimulation has been observed, and the picture of cartilage regeneration has been inconsequential. Barr and Bisgard and Hunt have called attention to the insults to the hemopoietic system in the metaphyses as revealed by the fibrous character of the marrow space. Careful measurements of long bones following exposure reveal not only less length than normal but decrease in shaft diameter and cortical thickness. The changes noted in hyaline joint cartilage are apparently insignificant from a clinical standpoint. The literature does not divulge a large number of cases in which longitudinal growth was followed after therapeutic irradiation about the epiphyses. Desjardins (4) reported the case of a nine-year old girl irradiated for a tumor of the upper humerus. The total dosage was not recorded. Five years following treatment there was marked shortening of the humerus with atrophy of the shoulder musculature. Stevens (9) over a period of two months gave a four-month-old child 1,816 r for a nevocarcinoma of the left thigh, lower abdomen, and vulva. The tumor was successfully controlled, but at the age of four years the left limb measured two inches shorter than the right. In the face of this retarded growth, Stevens urged great care in irradiating infants. Judy (5), in a preliminary report, described changes effected in three children submitted to irradiation in an attempt to correct asymmetry in the length of the lower extremities. The ages were five to eight years, and the discrepancy between the two limbs 1¼ to 3 inches." @default.
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• W2072476547 date "1950-11-01" @default.
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• W2072476547 title "Extreme Retardation of Epiphyseal Growth from Roentgen Irradiation" @default.
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