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- W2072482104 abstract "The chloroacetyl derivatives of four representative para-substituted phenylalanines, N-chloroacetyl-p-chloro-DL-phenylalanine, N-chloroacetyl-p-nitro-DL-phenylalanine, Na,Np-di(chloroacetyl)-p-amino-DL-phenylalanine, and N-chloroacetyl-O-methyl-L-tyrosine, were prepared and tested for growth inhibitory activity in Lactobacillus casei. The inhibition with these compounds approximated that of most other inhibitory chloroacetyl amino acids reported previously. However, N-chloroacetyl-p-chloro-DL-phenylalanine, the most active of these compounds, exhibited an activity approximately that of N-chloroacetyl-β-hydroxy-D-norleucine B, the most active N-chloroacetyl derivative studied thus far. In view of this finding, the N-chloroacetyl derivatives of other para-halogenated phenylalanines were prepared and jested. The inhibitory capacity of the N-chloroacetyl derivatives of p-bromo- and p-iodophenylalanine was even greater than that of p-chlorophenylalanine, and the order of activity of these compounds increased from the chloroacetyl derivative of p-chloro- to that of p-bromo- to that of p-iodo-DL-phenylalanine. The activity of N-chloroacetyl-p-bromo-and N-chloroacetyl-p-iodo-DL-phenylalanine was as great as that of the ring-substituted N-benzoylphenylalanines, the most potent N-acyl derivatives observed." @default.
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- W2072482104 date "1981-04-01" @default.
- W2072482104 modified "2023-09-23" @default.
- W2072482104 title "Effect of Chloroacetyl Derivatives of para-Substituted Phenylalanines on Microbial Antitumor Prescreens" @default.
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- W2072482104 doi "https://doi.org/10.1002/jps.2600700434" @default.
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