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• W2072483352 abstract "Significance The innate immune system is a highly conserved mode of defense that induces gene expression programs to restrict microbial infections. However, much remains unknown about how the target genes are poised for their rapid induction. Using a Drosophila model, we demonstrate that Nup98 plays an essential antiviral role in insects against human insect-borne viruses. Although Nup98 is known for its role in nuclear-cytoplasmic transport, our data suggest that this antiviral function is not at the nuclear pore, rather at promoters controlling expression of a subset of virus-induced genes. Our findings suggest that the Nup98 primes virus-stimulated genes by regulating the occupancy of active RNA polymerase at these promoters poising them for rapid induction, thereby coordinating a robust and complex antiviral response." @default.
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• W2072483352 date "2014-09-02" @default.
• W2072483352 modified "2023-10-12" @default.
• W2072483352 title "Nup98 promotes antiviral gene expression to restrict RNA viral infection in <i>Drosophila</i>" @default.
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• W2072483352 doi "https://doi.org/10.1073/pnas.1410087111" @default.
• W2072483352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4169978" @default.
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• W2072483352 hasPublicationYear "2014" @default.
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