FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072486082> ?p ?o ?g. }

• W2072486082 endingPage "664" @default.
• W2072486082 startingPage "654" @default.
• W2072486082 abstract "A conjugate between maleylated albumin and a photosensitizer (PS) shows cell type specific targeting to macrophages via the scavenger receptor. Administration of this conjugate to a tumor-bearing mouse followed by illumination may allow selective destruction of macrophages within tumors. There is accumulating evidence that tumor-associated macrophages contribute to tumor growth, invasiveness, metastasis, and immune suppression. We tested the intravenous (IV) injection of a conjugate between maleylated albumin and chlorin(e6) to BALB/c mice bearing three tumor types with differing proportions of tumor-associated macrophages. The accumulation of PS within the tumors after IV injection and 24 h incubation time was disappointing, and we therefore investigated intratumoral (IT) injection. This gave 20−50 times greater concentrations of PS within the tumor compared to IV injection as determined by tissue extraction. Furthermore the amounts of PS in each tumor type correlated well with the numbers of macrophages both as determined by extraction from bulk tumor and fluorescence quantification and as determined by tissue dissociation to a single cell suspension and two-color flow cytometry with macrophage-specific antibodies. IT injection of nonconjugated PS gave lower tumor accumulation that did not correlate with macrophage content. IT injection of targeted macromolecular delivery systems is an underexplored area and worthy of further study. Keywords: Tumor-associated macrophages; photosensitizer targeting; scavenger receptors; intratumoral injection; flow cytometry" @default.
• W2072486082 created "2016-06-24" @default.
• W2072486082 creator A5001374433 @default.
• W2072486082 creator A5003991710 @default.
• W2072486082 creator A5013534622 @default.
• W2072486082 creator A5039416069 @default.
• W2072486082 creator A5047900893 @default.
• W2072486082 creator A5067540046 @default.
• W2072486082 creator A5084273922 @default.
• W2072486082 date "2006-08-17" @default.
• W2072486082 modified "2023-09-26" @default.
• W2072486082 title "Macrophage-Targeted Photosensitizer Conjugate Delivered by Intratumoral Injection" @default.
• W2072486082 cites W142125945 @default.
• W2072486082 cites W1480357432 @default.
• W2072486082 cites W1596848781 @default.
• W2072486082 cites W1637697903 @default.
• W2072486082 cites W1865235773 @default.
• W2072486082 cites W1896092215 @default.
• W2072486082 cites W1936480433 @default.
• W2072486082 cites W1968095169 @default.
• W2072486082 cites W1971292240 @default.
• W2072486082 cites W1979104363 @default.
• W2072486082 cites W1980773592 @default.
• W2072486082 cites W1993046726 @default.
• W2072486082 cites W1993546257 @default.
• W2072486082 cites W2000439516 @default.
• W2072486082 cites W2009677760 @default.
• W2072486082 cites W2013806881 @default.
• W2072486082 cites W2024354916 @default.
• W2072486082 cites W2026889493 @default.
• W2072486082 cites W2029342537 @default.
• W2072486082 cites W2044674091 @default.
• W2072486082 cites W2049728797 @default.
• W2072486082 cites W2054603697 @default.
• W2072486082 cites W2061001430 @default.
• W2072486082 cites W2065229039 @default.
• W2072486082 cites W2074352896 @default.
• W2072486082 cites W2083336110 @default.
• W2072486082 cites W2087445098 @default.
• W2072486082 cites W2094704598 @default.
• W2072486082 cites W2096680191 @default.
• W2072486082 cites W2106123694 @default.
• W2072486082 cites W2109664798 @default.
• W2072486082 cites W2110287677 @default.
• W2072486082 cites W2117061676 @default.
• W2072486082 cites W2119423559 @default.
• W2072486082 cites W2125051557 @default.
• W2072486082 cites W2134315923 @default.
• W2072486082 cites W2149142217 @default.
• W2072486082 cites W2158770127 @default.
• W2072486082 cites W2159203898 @default.
• W2072486082 cites W2163878929 @default.
• W2072486082 cites W2170952917 @default.
• W2072486082 cites W2412540639 @default.
• W2072486082 cites W2415378978 @default.
• W2072486082 cites W2474616344 @default.
• W2072486082 cites W2767339943 @default.
• W2072486082 doi "https://doi.org/10.1021/mp060024y" @default.
• W2072486082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2504868" @default.
• W2072486082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17140253" @default.
• W2072486082 hasPublicationYear "2006" @default.
• W2072486082 type Work @default.
• W2072486082 sameAs 2072486082 @default.
• W2072486082 citedByCount "20" @default.
• W2072486082 countsByYear W20724860822013 @default.
• W2072486082 countsByYear W20724860822014 @default.
• W2072486082 countsByYear W20724860822015 @default.
• W2072486082 countsByYear W20724860822016 @default.
• W2072486082 countsByYear W20724860822017 @default.
• W2072486082 countsByYear W20724860822018 @default.
• W2072486082 countsByYear W20724860822020 @default.
• W2072486082 countsByYear W20724860822021 @default.
• W2072486082 countsByYear W20724860822023 @default.
• W2072486082 crossrefType "journal-article" @default.
• W2072486082 hasAuthorship W2072486082A5001374433 @default.
• W2072486082 hasAuthorship W2072486082A5003991710 @default.
• W2072486082 hasAuthorship W2072486082A5013534622 @default.
• W2072486082 hasAuthorship W2072486082A5039416069 @default.
• W2072486082 hasAuthorship W2072486082A5047900893 @default.
• W2072486082 hasAuthorship W2072486082A5067540046 @default.
• W2072486082 hasAuthorship W2072486082A5084273922 @default.
• W2072486082 hasBestOaLocation W20724860822 @default.
• W2072486082 hasConcept C121332964 @default.
• W2072486082 hasConcept C121608353 @default.
• W2072486082 hasConcept C126322002 @default.
• W2072486082 hasConcept C134306372 @default.
• W2072486082 hasConcept C153911025 @default.
• W2072486082 hasConcept C178790620 @default.
• W2072486082 hasConcept C185592680 @default.
• W2072486082 hasConcept C197336794 @default.
• W2072486082 hasConcept C202751555 @default.
• W2072486082 hasConcept C2776187077 @default.
• W2072486082 hasConcept C2778015030 @default.
• W2072486082 hasConcept C2778163477 @default.
• W2072486082 hasConcept C2779244956 @default.
• W2072486082 hasConcept C2780072125 @default.
• W2072486082 hasConcept C2781323092 @default.
• W2072486082 hasConcept C2781469039 @default.

• next