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• W2072487330 abstract "Desferrioxamine, the therapeutic iron chelator, is limited in its usage by its short half-life in plasma and lack of oral activity, its side-effects and its slow penetration into cells. Several studies have emerged recently demonstrating the ability of this trihydroxamate compound to act as a radical scavenger, in addition to and independently of its iron-chelating properties. These include the interaction of desferrioxamine with the Superoxide radical and ferryl myoglobin radical, as well as its action as a chainbreaking antioxidant in peroxidizing erythrocyte membranes. We have synthesized recently a series of monohydroxamate compounds and investigated their efficacy as radical scavenging antioxidants in comparison with desferrioxamine and rhodotorulic acid, a naturally occurring dihydroxamate compound. The results show that the relative rates of reaction of these hydroxamate derivatives with ferryl myoglobin are No-methyl-N-hexanoyl hydroxylamineN-methyl-N-benzoyl hydroxylaminN-methyl-N-acetyl ydroxylamine desferrioxamine rhodotorulic acidN-methyl-N-butyryl hydroxylamine." @default.
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• W2072487330 date "1993-01-01" @default.
• W2072487330 modified "2023-09-26" @default.
• W2072487330 title "The efficacy of monohydroxamates as free radical scavenging agents compared with di- and trihydroxamates" @default.
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• W2072487330 doi "https://doi.org/10.1016/0006-2952(93)90071-4" @default.
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