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- W2072488034 abstract "Mini-chromosome maintenance (MCM) proteins are the replicative helicase necessary for DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene. Here, we report a 1.8-Å crystal structure of the N-terminal MCM from the archaeon Thermoplasma acidophilum (tapMCM). In the structure, the MCM N-terminus forms a right-handed filament that contains six subunits in each turn, with a diameter of 25 Å of the central channel opening. The inner surface is highly positively charged, indicating DNA binding. This filament structure with six subunits per turn may also suggests a potential role for an open-ring structure for hexameric MCM and dynamic conformational changes in initiation and elongation stages of DNA replication." @default.
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- W2072488034 date "2014-04-01" @default.
- W2072488034 modified "2023-09-28" @default.
- W2072488034 title "The 1.8-Å Crystal Structure of the N-Terminal Domain of an Archaeal MCM as a Right-Handed Filament" @default.
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- W2072488034 doi "https://doi.org/10.1016/j.jmb.2013.12.025" @default.
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- W2072488034 hasPublicationYear "2014" @default.
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