FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072489662> ?p ?o ?g. }

• W2072489662 endingPage "589" @default.
• W2072489662 startingPage "557" @default.
• W2072489662 abstract "1. High-throughput screening approaches have been adopted throughout the pharmaceutical industry to aid in the rapid discovery of new chemical entities. Because it is now well recognized that the selection of a robust candidate requires a balance of potency, safety and pharmacokinetics, the role of drug metabolism departments has widened from their traditional one of supporting drug development to include the screening of compounds during the discovery process. To put drug metabolism and pharmacokinetic (DMPK) studies in context, the evolving role of DMPK screening in the drug discovery strategy of pharmaceutical companies will be discussed and a generalized approach will be presented. 2. With the increasing numbers of compounds requiring screening, DMPK optimization methods have had to be adapted for high throughput. There have been many developments in this field over the past decade and this review will focus on the high-throughput DMPK screening methodologies used today and in the recent past. 3. In vitro and in silico (computer-based) methods have proven most amenable to high-throughput approaches and these will firm the bulk of the review, but some advances with in vivo methods will also be discussed. As there has been a vast increase in published material on the topic of high-throughput DMPK methodologies in the past 10 years, it would be impossible to cover every method in detail, so this review will concentrate on the key areas and refer the reader to other, more detailed reviews wherever possible. 4. Most high-throughput methods would not be possible without the enabling technologies of computing, automation, new sample preparation technologies, and highly sensitive and selective detection systems, and these will also be reviewed. 5. The advantages and disadvantages of the screening methods will be presented, in particular the issue of handling the false-positives and -negatives that arise. 6. In concluding the review, future developments in this field will be discussed along with key issues that will need to be addressed." @default.
• W2072489662 created "2016-06-24" @default.
• W2072489662 creator A5083701532 @default.
• W2072489662 date "2001-01-01" @default.
• W2072489662 modified "2023-10-14" @default.
• W2072489662 title "High-throughput screening approaches for investigating drug metabolism and pharmacokinetics" @default.
• W2072489662 cites W1489601464 @default.
• W2072489662 cites W1502459074 @default.
• W2072489662 cites W1563896178 @default.
• W2072489662 cites W1566709868 @default.
• W2072489662 cites W1577971929 @default.
• W2072489662 cites W1970126106 @default.
• W2072489662 cites W1972889164 @default.
• W2072489662 cites W1973966996 @default.
• W2072489662 cites W1974129665 @default.
• W2072489662 cites W1974540791 @default.
• W2072489662 cites W1975930768 @default.
• W2072489662 cites W1979196526 @default.
• W2072489662 cites W1985356444 @default.
• W2072489662 cites W1987380529 @default.
• W2072489662 cites W1988733714 @default.
• W2072489662 cites W1991443437 @default.
• W2072489662 cites W1991972770 @default.
• W2072489662 cites W1992229282 @default.
• W2072489662 cites W1993047099 @default.
• W2072489662 cites W1999414126 @default.
• W2072489662 cites W2000658458 @default.
• W2072489662 cites W2001325110 @default.
• W2072489662 cites W2003237988 @default.
• W2072489662 cites W2003873735 @default.
• W2072489662 cites W2009649574 @default.
• W2072489662 cites W2009894278 @default.
• W2072489662 cites W2010595835 @default.
• W2072489662 cites W2011505858 @default.
• W2072489662 cites W2012225201 @default.
• W2072489662 cites W2012334764 @default.
• W2072489662 cites W2013572877 @default.
• W2072489662 cites W2013714261 @default.
• W2072489662 cites W201548973 @default.
• W2072489662 cites W2020753810 @default.
• W2072489662 cites W2021474803 @default.
• W2072489662 cites W2021508930 @default.
• W2072489662 cites W2021651928 @default.
• W2072489662 cites W2022320781 @default.
• W2072489662 cites W2031011202 @default.
• W2072489662 cites W2035768070 @default.
• W2072489662 cites W2037509330 @default.
• W2072489662 cites W2039673475 @default.
• W2072489662 cites W2043293421 @default.
• W2072489662 cites W2046827775 @default.
• W2072489662 cites W2047374720 @default.
• W2072489662 cites W2049415407 @default.
• W2072489662 cites W2055063236 @default.
• W2072489662 cites W2056818813 @default.
• W2072489662 cites W2060917067 @default.
• W2072489662 cites W2062801508 @default.
• W2072489662 cites W2064102714 @default.
• W2072489662 cites W2072027127 @default.
• W2072489662 cites W2079676258 @default.
• W2072489662 cites W2080068747 @default.
• W2072489662 cites W2080242559 @default.
• W2072489662 cites W2083064918 @default.
• W2072489662 cites W2083646919 @default.
• W2072489662 cites W2084466443 @default.
• W2072489662 cites W2087353625 @default.
• W2072489662 cites W2087815224 @default.
• W2072489662 cites W2089250398 @default.
• W2072489662 cites W2090306099 @default.
• W2072489662 cites W2092118786 @default.
• W2072489662 cites W2095283870 @default.
• W2072489662 cites W2095884861 @default.
• W2072489662 cites W2101325513 @default.
• W2072489662 cites W2117753715 @default.
• W2072489662 cites W212063617 @default.
• W2072489662 cites W2125848836 @default.
• W2072489662 cites W2125876729 @default.
• W2072489662 cites W2134344823 @default.
• W2072489662 cites W2151681059 @default.
• W2072489662 cites W2161723120 @default.
• W2072489662 cites W2322517927 @default.
• W2072489662 cites W237674313 @default.
• W2072489662 cites W2419957334 @default.
• W2072489662 cites W2483004373 @default.
• W2072489662 cites W264483085 @default.
• W2072489662 cites W2949243165 @default.
• W2072489662 cites W4239606543 @default.
• W2072489662 cites W4248107770 @default.
• W2072489662 doi "https://doi.org/10.1080/00498250110060978" @default.
• W2072489662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11569526" @default.
• W2072489662 hasPublicationYear "2001" @default.
• W2072489662 type Work @default.
• W2072489662 sameAs 2072489662 @default.
• W2072489662 citedByCount "90" @default.
• W2072489662 countsByYear W20724896622012 @default.
• W2072489662 countsByYear W20724896622013 @default.
• W2072489662 countsByYear W20724896622014 @default.
• W2072489662 countsByYear W20724896622015 @default.
• W2072489662 countsByYear W20724896622017 @default.

• next