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- W2072492018 abstract "Cells of Saccharomycescerevisiae, harvested from log phase cultures, contain cytochrome P-450 and are capable of activating promutagens to products that are genetically active in the same cell. The effect of cumene hydroperoxide, a compound known to support cytochrome P-450-mediated reactions, on the activation of a variety of the promutagens was investigated. In all cases the genetic activity of the promutagens was increased. With dimethyl-nitrosamine as the promutagen, the increased rate of gene conversion was linear for at least 1 hr. Yeast cytochrome P-450 was stable in intact cells in the presence of cumene hydroperoxide. However, in microsomal preparations the cytochrome was rapidly destroyed. When cumene hydroperoxide was added to a suspension of intact yeast cells, a spectrum with a Soret maximum at 455 nm — indicative of an interaction with cytochrome P-450 — was observed." @default.
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- W2072492018 date "1978-07-01" @default.
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- W2072492018 title "Cumene hydroperoxide and yeast cytochrome P-450: Spectral interactions and effect on the genetic activity of promutagens" @default.
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- W2072492018 doi "https://doi.org/10.1016/0006-291x(78)90391-1" @default.
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