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• W2072498081 abstract "Editing and alternative splicing of mRNA are posttranscriptional steps probably involved in pathophysiological aspects of epilepsy. The present study analyses the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR2 with respect to the expression of (i) editing at the R/G site and (ii) flip–flop cassettes. Nervous tissue from patients with temporal lobe epilepsy was analysed by RT-PCR followed by restriction enzyme assays. Human autoptic tissue served as control. R/G editing status: the relative amount of edited RNA was significantly increased in the hippocampal tissue, whereas no changes were found in neocortical tissues. Flip–flop expression: no significant alterations were found in relative abundance of spliced variants containing the flip exon. The increased editing at the R/G site in the hippocampal tissue of epilepsy patients may enhance responses to glutamate, resulting in a synapse operating at an increased gain." @default.
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• W2072498081 date "2004-03-01" @default.
• W2072498081 modified "2023-09-27" @default.
• W2072498081 title "RNA editing (R/G site) and flip–flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients" @default.
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• W2072498081 doi "https://doi.org/10.1016/j.nbd.2003.11.006" @default.
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