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- W2072510183 endingPage "19" @default.
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- W2072510183 abstract "Oral contraceptives (OC) may cause intrahepatic cholestasis or increase a pre-established liver damage. OC effects on hepatic injury biochemical markers remain contradictory and the role of cytokines in those processes is fairly unknown. Two doses, simple or double, of the OC combination ethinylestradiol/norgestrel were administered during 14 or 28 days to normal and cholestatic female rats. Liver damage markers and the cytokines tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) were determined in plasma and liver. OC caused ambiguous results on cholestasis indicators, even more in cholestatic rats. Necrosis rose during cholestasis while OC lowered it in normal rats. Fibrosis was induced by cholestasis but OC double dose or intake time diminished that. Cholestasis depleted glycogen while OC did not alter it. Double dose or time of administration of OC significantly elevated the lipid peroxidation. Cholestasis modified plasma and liver cytokines but OC remarkably altered them in normal and cholestatic animals. TNF-α as well as IL-10 were increased in both tissues by OC, such rise was higher in normal rats. TGF-β was augmented by OC and more in cholestatic rats receiving double dose. Thus, OC modified most liver injury markers in normal rats although more pronouncedly in cholestatic ones, as well as increased hepatic oxidative stress. Liver fibrosis was decreased and corroborated by histological analysis even when TGF-β is elevated by OC. OC strongly immunomodulate cytokines that mediate liver damage or worsen a prior hepatopathy; those processes are influenced by dose, administration time and OC formulation." @default.
- W2072510183 created "2016-06-24" @default.
- W2072510183 creator A5015461196 @default.
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- W2072510183 creator A5071981212 @default.
- W2072510183 creator A5088709113 @default.
- W2072510183 date "2014-07-01" @default.
- W2072510183 modified "2023-09-23" @default.
- W2072510183 title "Immunomodulatory effects by oral contraceptives in normal and cholestatic female rats: Role of cytokines" @default.
- W2072510183 cites W146849824 @default.
- W2072510183 cites W1493699175 @default.
- W2072510183 cites W1529489570 @default.
- W2072510183 cites W1595500473 @default.
- W2072510183 cites W1880996918 @default.
- W2072510183 cites W1963572882 @default.
- W2072510183 cites W1965101335 @default.
- W2072510183 cites W1965739003 @default.
- W2072510183 cites W1966086522 @default.
- W2072510183 cites W1966570481 @default.
- W2072510183 cites W1968098524 @default.
- W2072510183 cites W1969567016 @default.
- W2072510183 cites W1971094896 @default.
- W2072510183 cites W1972342323 @default.
- W2072510183 cites W1974813804 @default.
- W2072510183 cites W1975745166 @default.
- W2072510183 cites W1981020323 @default.
- W2072510183 cites W1983310681 @default.
- W2072510183 cites W1983779522 @default.
- W2072510183 cites W1983790242 @default.
- W2072510183 cites W1994955127 @default.
- W2072510183 cites W2005317484 @default.
- W2072510183 cites W2006525265 @default.
- W2072510183 cites W2007882007 @default.
- W2072510183 cites W2010860353 @default.
- W2072510183 cites W2011072836 @default.
- W2072510183 cites W201260118 @default.
- W2072510183 cites W2016193333 @default.
- W2072510183 cites W2017025371 @default.
- W2072510183 cites W2017698887 @default.
- W2072510183 cites W2020687039 @default.
- W2072510183 cites W2021575753 @default.
- W2072510183 cites W2027090616 @default.
- W2072510183 cites W2027154705 @default.
- W2072510183 cites W2029253842 @default.
- W2072510183 cites W2032769873 @default.
- W2072510183 cites W2038774702 @default.
- W2072510183 cites W2039937486 @default.
- W2072510183 cites W2041448864 @default.
- W2072510183 cites W2043057804 @default.
- W2072510183 cites W2044369927 @default.
- W2072510183 cites W2052158431 @default.
- W2072510183 cites W2052571684 @default.
- W2072510183 cites W2052977972 @default.
- W2072510183 cites W2054893546 @default.
- W2072510183 cites W2060008624 @default.
- W2072510183 cites W2060859185 @default.
- W2072510183 cites W2061542347 @default.
- W2072510183 cites W2064547810 @default.
- W2072510183 cites W2064886603 @default.
- W2072510183 cites W2070347103 @default.
- W2072510183 cites W2072510263 @default.
- W2072510183 cites W2080325240 @default.
- W2072510183 cites W2082378013 @default.
- W2072510183 cites W2085227436 @default.
- W2072510183 cites W2091724428 @default.
- W2072510183 cites W2095561322 @default.
- W2072510183 cites W2098931680 @default.
- W2072510183 cites W2104076834 @default.
- W2072510183 cites W2107907724 @default.
- W2072510183 cites W2108536114 @default.
- W2072510183 cites W2110663903 @default.
- W2072510183 cites W2114412948 @default.
- W2072510183 cites W2117054419 @default.
- W2072510183 cites W2120966370 @default.
- W2072510183 cites W2126128710 @default.
- W2072510183 cites W2129151935 @default.
- W2072510183 cites W2129940653 @default.
- W2072510183 cites W2131891237 @default.
- W2072510183 cites W2135745273 @default.
- W2072510183 cites W2142154375 @default.
- W2072510183 cites W2154944050 @default.
- W2072510183 cites W2156688711 @default.
- W2072510183 cites W2163369593 @default.
- W2072510183 cites W2164080063 @default.
- W2072510183 cites W2167028176 @default.
- W2072510183 cites W2167423656 @default.
- W2072510183 cites W2171405695 @default.
- W2072510183 cites W2263023695 @default.
- W2072510183 cites W2279627984 @default.
- W2072510183 cites W2406451963 @default.
- W2072510183 cites W4252498366 @default.
- W2072510183 cites W4255712601 @default.
- W2072510183 cites W4293247451 @default.
- W2072510183 cites W6772648 @default.
- W2072510183 cites W7877914 @default.