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• W2072530682 abstract "The protein kinase inhibitor staurosporine was found to be a potent relaxant of rabbit aortic strips contracted by various agonists. This relaxing effect was slow, long-lasting and in a non-competitive fashion against various agonists. The effect of staurosporine on the KCl-induced contraction was not altered by atropine, propranolol, theophylline or indomethacin. Staurosporine (5-200 nM) inhibited the contractile responses to prostaglandin F2 alpha (3 microM), endothelin (0.1 microM), phenylephrine (3 microM) and KCl (30 mM), with ED50 values of 10.8 +/- 0.6, 24.6 +/- 8.7, 48.8 +/- 7.0, 54.0 +/- 12.7 nM, respectively. Even in Ca(2+)-free physiological salt solution, staurosporine potently antagonized the contractile responses elicited by 10 microM prostaglandin F2 alpha and 0.1 microM endothelin; in fact it was more effective than it was in normal Ca2+ solution: ED50 of 11.3 +/- 3.8 vs. 21.0 +/- 4.4 nM (P less than 0.02), and of 10.6 +/- 3.6 vs. 24.6 +/- 4.3 nM (P less than 0.01), respectively. Thus, staurosporine has an equipotent inhibitory action on intracellular and extracellular calcium-dependent contractions of aortic tissues." @default.
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• W2072530682 date "1991-09-01" @default.
• W2072530682 modified "2023-10-18" @default.
• W2072530682 title "Staurosporine, a protein kinase inhibitor, attenuates intracellular Ca2+ -dependent contractions of strips of rabbit aorta" @default.
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• W2072530682 doi "https://doi.org/10.1016/0014-2999(91)90280-4" @default.
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