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• W2072531353 endingPage "69" @default.
• W2072531353 startingPage "33" @default.
• W2072531353 abstract "Calsequestrin is by far the most abundant Ca(2+)-binding protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It allows the Ca2+ required for contraction to be stored at total concentrations of up to 20mM, while the free Ca2+ concentration remains at approximately 1mM. This storage capacity confers upon muscle the ability to contract frequently with minimal run-down in tension. Calsequestrin is highly acidic, containing up to 50 Ca(2+)-binding sites, which are formed simply by clustering of two or more acidic residues. The Kd for Ca2+ binding is between 1 and 100 microM, depending on the isoform, species and the presence of other cations. Calsequestrin monomers have a molecular mass of approximately 40 kDa and contain approximately 400 residues. The monomer contains three domains each with a compact alpha-helical/beta-sheet thioredoxin fold which is stable in the presence of Ca2+. The protein polymerises when Ca2+ concentrations approach 1mM. The polymer is anchored at one end to ryanodine receptor (RyR) Ca2+ release channels either via the intrinsic membrane proteins triadin and junctin or by binding directly to the RyR. It is becoming clear that calsequestrin has several functions in the lumen of the SR in addition to its well-recognised role as a Ca2+ buffer. Firstly, it is a luminal regulator of RyR activity. When triadin and junctin are present, calsequestrin maximally inhibits the Ca2+ release channel when the free Ca2+ concentration in the SR lumen is 1mM. The inhibition is relieved when the Ca2+ concentration alters, either because of small changes in the conformation of calsequestrin or its dissociation from the junctional face membrane. These changes in calsequestrin's association with the RyR amplify the direct effects of luminal Ca2+ concentration on RyR activity. In addition, calsequestrin activates purified RyRs lacking triadin and junctin. Further roles for calsequestrin are indicated by the kinase activity of the protein, its thioredoxin-like structure and its influence over store operated Ca2+ entry. Clearly, calsequestrin plays a major role in calcium homeostasis that extends well beyond its ability to buffer Ca2+ ions." @default.
• W2072531353 created "2016-06-24" @default.
• W2072531353 creator A5049563006 @default.
• W2072531353 creator A5066629521 @default.
• W2072531353 creator A5085253794 @default.
• W2072531353 date "2004-05-01" @default.
• W2072531353 modified "2023-09-30" @default.
• W2072531353 title "Calsequestrin and the calcium release channel of skeletal and cardiac muscle" @default.
• W2072531353 cites W107810048 @default.
• W2072531353 cites W12635643 @default.
• W2072531353 cites W1480415840 @default.
• W2072531353 cites W1481469889 @default.
• W2072531353 cites W1482605569 @default.
• W2072531353 cites W1500397819 @default.
• W2072531353 cites W1509611865 @default.
• W2072531353 cites W1510616039 @default.
• W2072531353 cites W1511319117 @default.
• W2072531353 cites W1515292518 @default.
• W2072531353 cites W1525891657 @default.
• W2072531353 cites W1527461658 @default.
• W2072531353 cites W1531532159 @default.
• W2072531353 cites W1531765690 @default.
• W2072531353 cites W1533171224 @default.
• W2072531353 cites W1534652943 @default.
• W2072531353 cites W1537623701 @default.
• W2072531353 cites W1538531107 @default.
• W2072531353 cites W1539182280 @default.
• W2072531353 cites W1542999239 @default.
• W2072531353 cites W1548520611 @default.
• W2072531353 cites W1556184133 @default.
• W2072531353 cites W1558794683 @default.
• W2072531353 cites W1563422013 @default.
• W2072531353 cites W1574440719 @default.
• W2072531353 cites W1593535214 @default.
• W2072531353 cites W1597268103 @default.
• W2072531353 cites W1895697393 @default.
• W2072531353 cites W1964709412 @default.
• W2072531353 cites W1965095855 @default.
• W2072531353 cites W1967299083 @default.
• W2072531353 cites W1968403224 @default.
• W2072531353 cites W1968408785 @default.
• W2072531353 cites W1971833900 @default.
• W2072531353 cites W1973150566 @default.
• W2072531353 cites W1974535915 @default.
• W2072531353 cites W1975002626 @default.
• W2072531353 cites W1976690731 @default.
• W2072531353 cites W1979437797 @default.
• W2072531353 cites W1982765384 @default.
• W2072531353 cites W1983719040 @default.
• W2072531353 cites W1987523382 @default.
• W2072531353 cites W1987881503 @default.
• W2072531353 cites W1988129679 @default.
• W2072531353 cites W1989553550 @default.
• W2072531353 cites W1991605997 @default.
• W2072531353 cites W1991616039 @default.
• W2072531353 cites W1992127649 @default.
• W2072531353 cites W1993315491 @default.
• W2072531353 cites W1993401199 @default.
• W2072531353 cites W1994693592 @default.
• W2072531353 cites W1995526208 @default.
• W2072531353 cites W1995718962 @default.
• W2072531353 cites W2001479401 @default.
• W2072531353 cites W2001749475 @default.
• W2072531353 cites W2002885745 @default.
• W2072531353 cites W2003599324 @default.
• W2072531353 cites W2005908710 @default.
• W2072531353 cites W2007062222 @default.
• W2072531353 cites W2007709380 @default.
• W2072531353 cites W2007826097 @default.
• W2072531353 cites W2010845408 @default.
• W2072531353 cites W2013070374 @default.
• W2072531353 cites W2013578935 @default.
• W2072531353 cites W2015963233 @default.
• W2072531353 cites W2016850966 @default.
• W2072531353 cites W2017268780 @default.
• W2072531353 cites W2020672475 @default.
• W2072531353 cites W2021159562 @default.
• W2072531353 cites W2023609755 @default.
• W2072531353 cites W2024391217 @default.
• W2072531353 cites W2025065705 @default.
• W2072531353 cites W2026100844 @default.
• W2072531353 cites W2026644592 @default.
• W2072531353 cites W2028421228 @default.
• W2072531353 cites W2028807910 @default.
• W2072531353 cites W2029199558 @default.
• W2072531353 cites W2029790439 @default.
• W2072531353 cites W2032504754 @default.
• W2072531353 cites W2032894671 @default.
• W2072531353 cites W2034117958 @default.
• W2072531353 cites W2035672028 @default.
• W2072531353 cites W2036147775 @default.
• W2072531353 cites W2038013299 @default.
• W2072531353 cites W2039547987 @default.
• W2072531353 cites W2039625439 @default.
• W2072531353 cites W2039932112 @default.
• W2072531353 cites W2040737229 @default.
• W2072531353 cites W2043520657 @default.
• W2072531353 cites W2045339420 @default.

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