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- W2072534413 abstract "To the Editor: The study by Ganguli et al.1 certainly highlights mental health issues faced by older people living in rural areas. They report that half the tricyclics prescribed were at doses less than minimum recommended doses for geriatric depression, which may be of concern. This practice of reducing tricyclic dosages has been studied by us in a double-blind, randomized, controlled study. Although the study was performed on older patients in an inpatient setting and not in the community, we found that the low-dose tricyclic (one-third recommended dose of lofepramine, a pro drug of desipramine) was useful for reversing moderate and severe depression.2 However, we found that the low-dose tricyclic was ineffective for treating mild depression as the placebo achieved the same effect. Thus, we argue that low-dose tricyclic antidepressants are effective in treating major depression in older people.3 Using low doses of tricyclic antidepressants is particularly useful for older patients because they are more likely to develop anticholinergic side effects from treatment.4 It is our belief that biological half-life and therapeutic half-life of tricyclics may indeed be different2 and that prescribing lower doses of tricyclics for older people is not an unacceptable practice." @default.
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- W2072534413 date "1998-04-01" @default.
- W2072534413 modified "2023-09-23" @default.
- W2072534413 title "PRESCRIBING LESS THAN RECOMMENDED DOSES MAY BE ACCEPTABLE FOR GERIATRIC PATIENTS" @default.
- W2072534413 cites W1983021432 @default.
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- W2072534413 doi "https://doi.org/10.1111/j.1532-5415.1998.tb02482.x" @default.
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