Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072534480> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2072534480 endingPage "3662" @default.
- W2072534480 startingPage "3653" @default.
- W2072534480 abstract "Elevated nocturnal melatonin is found in women with idiopathic hypogonadotropic hypogonadism (IHH), but it is not known whether this is implicated in the etiology of their GnRH deficiency. It is unlikely that nocturnal melatonin can be implicated in the etiology of the GnRH deficiency of Kallmann's syndrome (KS), because this condition is caused by defective neuronal migration in embryonic life. We therefore measured nocturnal melatonin in women with IHH and KS to determine whether it was elevated in one or both conditions and thereby to determine whether it was implicated as cause or consequence of GnRH deficiency. Four women with IHH, 3 women with KS, and 7 individually matched (age and body size) controls were recruited. Frequent day- and nighttime samples were taken for LH pulsatility studies. All patients showed absent or diminished LH pulsatility, compared with their respective controls. Samples were also taken over 24 h for melatonin and 6-sulphatoxymelatonin (the principle metabolite of melatonin and an independent marker of its secretion). Melatonin and 6-sulphatoxymelatonin levels were elevated in 6 of 7 patients (compared with their matched controls) and were significantly elevated in the KS group (compared with their controls). The finding of elevated nocturnal melatonin (and its metabolite) in GnRH-deficient women with KS (as well as IHH) suggests that nocturnal melatonin is elevated as a consequence of GnRH deficiency, irrespective of its etiology." @default.
- W2072534480 created "2016-06-24" @default.
- W2072534480 creator A5014316696 @default.
- W2072534480 creator A5019783220 @default.
- W2072534480 creator A5022033792 @default.
- W2072534480 creator A5032596497 @default.
- W2072534480 creator A5035015234 @default.
- W2072534480 date "1998-10-01" @default.
- W2072534480 modified "2023-10-16" @default.
- W2072534480 title "Elevated Nocturnal Melatonin Is a Consequence of Gonadotropin-Releasing Hormone Deficiency in Women with Hypothalamic Amenorrhea" @default.
- W2072534480 cites W1750158896 @default.
- W2072534480 cites W1959192320 @default.
- W2072534480 cites W1970095826 @default.
- W2072534480 cites W1993990081 @default.
- W2072534480 cites W2009634330 @default.
- W2072534480 cites W2012845155 @default.
- W2072534480 cites W2041132592 @default.
- W2072534480 cites W2045854255 @default.
- W2072534480 cites W2067370433 @default.
- W2072534480 cites W2070745891 @default.
- W2072534480 cites W2083812399 @default.
- W2072534480 cites W2089470559 @default.
- W2072534480 cites W2128806138 @default.
- W2072534480 cites W2158874366 @default.
- W2072534480 cites W2285959147 @default.
- W2072534480 cites W2417851924 @default.
- W2072534480 doi "https://doi.org/10.1210/jcem.83.10.5155" @default.
- W2072534480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9768680" @default.
- W2072534480 hasPublicationYear "1998" @default.
- W2072534480 type Work @default.
- W2072534480 sameAs 2072534480 @default.
- W2072534480 citedByCount "24" @default.
- W2072534480 countsByYear W20725344802015 @default.
- W2072534480 countsByYear W20725344802019 @default.
- W2072534480 countsByYear W20725344802021 @default.
- W2072534480 crossrefType "journal-article" @default.
- W2072534480 hasAuthorship W2072534480A5014316696 @default.
- W2072534480 hasAuthorship W2072534480A5019783220 @default.
- W2072534480 hasAuthorship W2072534480A5022033792 @default.
- W2072534480 hasAuthorship W2072534480A5032596497 @default.
- W2072534480 hasAuthorship W2072534480A5035015234 @default.
- W2072534480 hasBestOaLocation W20725344801 @default.
- W2072534480 hasConcept C126322002 @default.
- W2072534480 hasConcept C134018914 @default.
- W2072534480 hasConcept C2777334680 @default.
- W2072534480 hasConcept C2778182776 @default.
- W2072534480 hasConcept C2778575703 @default.
- W2072534480 hasConcept C2778782382 @default.
- W2072534480 hasConcept C2778894405 @default.
- W2072534480 hasConcept C2781255401 @default.
- W2072534480 hasConcept C71315377 @default.
- W2072534480 hasConcept C71924100 @default.
- W2072534480 hasConceptScore W2072534480C126322002 @default.
- W2072534480 hasConceptScore W2072534480C134018914 @default.
- W2072534480 hasConceptScore W2072534480C2777334680 @default.
- W2072534480 hasConceptScore W2072534480C2778182776 @default.
- W2072534480 hasConceptScore W2072534480C2778575703 @default.
- W2072534480 hasConceptScore W2072534480C2778782382 @default.
- W2072534480 hasConceptScore W2072534480C2778894405 @default.
- W2072534480 hasConceptScore W2072534480C2781255401 @default.
- W2072534480 hasConceptScore W2072534480C71315377 @default.
- W2072534480 hasConceptScore W2072534480C71924100 @default.
- W2072534480 hasIssue "10" @default.
- W2072534480 hasLocation W20725344801 @default.
- W2072534480 hasLocation W20725344802 @default.
- W2072534480 hasOpenAccess W2072534480 @default.
- W2072534480 hasPrimaryLocation W20725344801 @default.
- W2072534480 hasRelatedWork W1975686996 @default.
- W2072534480 hasRelatedWork W1980207544 @default.
- W2072534480 hasRelatedWork W1993990081 @default.
- W2072534480 hasRelatedWork W2023835522 @default.
- W2072534480 hasRelatedWork W2052448036 @default.
- W2072534480 hasRelatedWork W2064667462 @default.
- W2072534480 hasRelatedWork W2072823512 @default.
- W2072534480 hasRelatedWork W2091241485 @default.
- W2072534480 hasRelatedWork W2162811903 @default.
- W2072534480 hasRelatedWork W4239046085 @default.
- W2072534480 hasVolume "83" @default.
- W2072534480 isParatext "false" @default.
- W2072534480 isRetracted "false" @default.
- W2072534480 magId "2072534480" @default.
- W2072534480 workType "article" @default.