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- W2072538822 abstract "We have compared the results of four bilirubin binding tests performed simultaneously on blood samples collected from jaundiced newborn infants with serum bilirubin concentrations ranging from 7.3-34.4 mg/dl. Data from 176 blood samples were correlated using the Pearson (r) and Spearman(rho) correlation coefficients. Salicylate saturation index (SSI) correlated with the HBABA dye binding test (HABA)(r= -.16,rho= -.14, P<.05), the horseradish peroxidase apparent unbound bilirubin concentration (AUBC) (r=.45, rho= .48,P<.001), and the direct yellow fluorescent dye binding test (DY7) (r= -.43, rho= -.57, P<.001). Each test correlated significantly with the others using parametric and non-parametric methods. However,none of the bilirubin binding tests correlate well enough with another that one test could be used clinically to predict the value of the other. The clinically derived thresholds (danger points) for each binding test did correlate with those of the others when regression lines were drawn using the least squares method. We conclude that the four tests measure similar, but not identical, properties of icteric infant sera and that correlations are not close enough to allow the results of one test to predict another. It is not possible to tell which test predicts clinical risk to bilirubin toxicity most reliably by this analysis. Only SSI and HABA have undergone clinical validation using long-term outcome of infants as the endpoint, each with one published study." @default.
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- W2072538822 date "1984-04-01" @default.
- W2072538822 modified "2023-09-26" @default.
- W2072538822 title "COMPARISON OF FOUR BILIRUBIN BINDING TESTS" @default.
- W2072538822 doi "https://doi.org/10.1203/00006450-198404001-01484" @default.
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