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- W2072542761 abstract "Some vinyl polymers by fixing 5FUs via carbamoyl bonds on organosilicon groups were synthesized by means of ordinary radical polymerization of the corresponding monomers. These hybrid type vinyl polymers with 5FU and or ganosilicon amine units exhibited significant antitumor activities against p-388 lymphocytic leukemia in mice in vivo (i.p./i.p.). The effects of the molecu lar weight, the hydrophobicity of the polymer carrier, the number of methy lenes in the spacer group, and the presence of silicon on the antitumor activity were investigated. The low molecular weight homopolymer of 5-fluoro-3,4-dihy dro-2,4-dioxo-N-(4,4-dimethyl-4-silahex-5-enyl)-1-(2H)-pyrimidinecarboxamide (KY20), Poly(KY-20), and the copolymer of KY-20 with 2-hydroxyethylmeth acrylate, Poly(KY-20/HEMA), exhibited especially high antitumor activities. The polymers obtained did not display an acute toxicity in the dose range of 25-800 mg/kg. Thus, these polymers were suggested to act as macromolecular prodrugs of 5FU." @default.
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- W2072542761 date "1988-01-01" @default.
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- W2072542761 title "Synthesis of Vinyl Polymer by Fixing 5-Fluorouracils through Organosilicon Groups via Carbamoyl Bonds and Its Antitumor Activity" @default.
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- W2072542761 doi "https://doi.org/10.1177/088391158800300106" @default.
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