FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072544476> ?p ?o ?g. }

• W2072544476 endingPage "4686" @default.
• W2072544476 startingPage "4676" @default.
• W2072544476 abstract "Nanoparticles in porous microparticles (NPinPMP), a novel delivery system for sustained delivery of protein drugs, was developed using supercritical infusion and pressure quench technology, which does not expose proteins to organic solvents or sonication. The delivery system design is based on the ability of supercritical carbon dioxide (SC CO2) to expand poly(lactic-co-glycolic) acid (PLGA) matrix but not polylactic acid (PLA) matrix. The technology was applied to bevacizumab, a protein drug administered once a month intravitreally to treat wet age related macular degeneration. Bevacizumab coated PLA nanoparticles were encapsulated into porosifying PLGA microparticles by exposing the mixture to SC CO2. After SC CO2 exposure, the size of PLGA microparticles increased by 6.9-fold. Confocal and scanning electron microscopy studies demonstrated the expansion and porosification of PLGA microparticles and infusion of PLA nanoparticles inside PLGA microparticles. In vitro release of bevacizumab from NPinPMP was sustained for 4 months. Size exclusion chromatography, fluorescence spectroscopy, circular dichroism spectroscopy, SDS-PAGE, and ELISA studies indicated that the released bevacizumab maintained its monomeric form, conformation, and activity. Further, in vivo delivery of bevacizumab from NPinPMP was evaluated using noninvasive fluorophotometry after intravitreal administration of Alexa Fluor 488 conjugated bevacizumab in either solution or NPinPMP in a rat model. Unlike the vitreal signal from Alexa-bevacizumab solution, which reached baseline at 2 weeks, release of Alexa-bevacizumab from NPinPMP could be detected for 2 months. Thus, NPinPMP is a novel sustained release system for protein drugs to reduce frequency of protein injections in the therapy of back of the eye diseases." @default.
• W2072544476 created "2016-06-24" @default.
• W2072544476 creator A5004778896 @default.
• W2072544476 creator A5053639264 @default.
• W2072544476 creator A5059534716 @default.
• W2072544476 creator A5081322848 @default.
• W2072544476 date "2013-11-12" @default.
• W2072544476 modified "2023-10-10" @default.
• W2072544476 title "Nanoparticles in Porous Microparticles Prepared by Supercritical Infusion and Pressure Quench Technology for Sustained Delivery of Bevacizumab" @default.
• W2072544476 cites W1539664785 @default.
• W2072544476 cites W1547433582 @default.
• W2072544476 cites W1696340081 @default.
• W2072544476 cites W1993966166 @default.
• W2072544476 cites W1996320203 @default.
• W2072544476 cites W2006143850 @default.
• W2072544476 cites W2014311047 @default.
• W2072544476 cites W2022981155 @default.
• W2072544476 cites W2042261909 @default.
• W2072544476 cites W2056090633 @default.
• W2072544476 cites W2058464257 @default.
• W2072544476 cites W2072033476 @default.
• W2072544476 cites W2072804003 @default.
• W2072544476 cites W2077485813 @default.
• W2072544476 cites W2094829349 @default.
• W2072544476 cites W2107027855 @default.
• W2072544476 cites W2110416036 @default.
• W2072544476 cites W2110849286 @default.
• W2072544476 cites W2121496050 @default.
• W2072544476 cites W2157508553 @default.
• W2072544476 cites W2161765731 @default.
• W2072544476 cites W2165066800 @default.
• W2072544476 cites W2183649757 @default.
• W2072544476 cites W3194796682 @default.
• W2072544476 cites W4242047572 @default.
• W2072544476 cites W4244094502 @default.
• W2072544476 cites W4252511080 @default.
• W2072544476 doi "https://doi.org/10.1021/mp400487f" @default.
• W2072544476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4004035" @default.
• W2072544476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24131101" @default.
• W2072544476 hasPublicationYear "2013" @default.
• W2072544476 type Work @default.
• W2072544476 sameAs 2072544476 @default.
• W2072544476 citedByCount "82" @default.
• W2072544476 countsByYear W20725444762014 @default.
• W2072544476 countsByYear W20725444762015 @default.
• W2072544476 countsByYear W20725444762016 @default.
• W2072544476 countsByYear W20725444762017 @default.
• W2072544476 countsByYear W20725444762018 @default.
• W2072544476 countsByYear W20725444762019 @default.
• W2072544476 countsByYear W20725444762020 @default.
• W2072544476 countsByYear W20725444762021 @default.
• W2072544476 countsByYear W20725444762022 @default.
• W2072544476 countsByYear W20725444762023 @default.
• W2072544476 crossrefType "journal-article" @default.
• W2072544476 hasAuthorship W2072544476A5004778896 @default.
• W2072544476 hasAuthorship W2072544476A5053639264 @default.
• W2072544476 hasAuthorship W2072544476A5059534716 @default.
• W2072544476 hasAuthorship W2072544476A5081322848 @default.
• W2072544476 hasBestOaLocation W20725444762 @default.
• W2072544476 hasConcept C121332964 @default.
• W2072544476 hasConcept C136229726 @default.
• W2072544476 hasConcept C141071460 @default.
• W2072544476 hasConcept C150903083 @default.
• W2072544476 hasConcept C155672457 @default.
• W2072544476 hasConcept C163588942 @default.
• W2072544476 hasConcept C171250308 @default.
• W2072544476 hasConcept C178790620 @default.
• W2072544476 hasConcept C185592680 @default.
• W2072544476 hasConcept C192562407 @default.
• W2072544476 hasConcept C207001950 @default.
• W2072544476 hasConcept C2776694085 @default.
• W2072544476 hasConcept C2776759294 @default.
• W2072544476 hasConcept C2777802072 @default.
• W2072544476 hasConcept C2779820397 @default.
• W2072544476 hasConcept C2780165375 @default.
• W2072544476 hasConcept C43617362 @default.
• W2072544476 hasConcept C62520636 @default.
• W2072544476 hasConcept C71924100 @default.
• W2072544476 hasConcept C86803240 @default.
• W2072544476 hasConcept C91881484 @default.
• W2072544476 hasConceptScore W2072544476C121332964 @default.
• W2072544476 hasConceptScore W2072544476C136229726 @default.
• W2072544476 hasConceptScore W2072544476C141071460 @default.
• W2072544476 hasConceptScore W2072544476C150903083 @default.
• W2072544476 hasConceptScore W2072544476C155672457 @default.
• W2072544476 hasConceptScore W2072544476C163588942 @default.
• W2072544476 hasConceptScore W2072544476C171250308 @default.
• W2072544476 hasConceptScore W2072544476C178790620 @default.
• W2072544476 hasConceptScore W2072544476C185592680 @default.
• W2072544476 hasConceptScore W2072544476C192562407 @default.
• W2072544476 hasConceptScore W2072544476C207001950 @default.
• W2072544476 hasConceptScore W2072544476C2776694085 @default.
• W2072544476 hasConceptScore W2072544476C2776759294 @default.
• W2072544476 hasConceptScore W2072544476C2777802072 @default.
• W2072544476 hasConceptScore W2072544476C2779820397 @default.
• W2072544476 hasConceptScore W2072544476C2780165375 @default.
• W2072544476 hasConceptScore W2072544476C43617362 @default.
• W2072544476 hasConceptScore W2072544476C62520636 @default.

• next