FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072548201> ?p ?o ?g. }

• W2072548201 endingPage "3353" @default.
• W2072548201 startingPage "3350" @default.
• W2072548201 abstract "Glutathione (GSH) and related enzymes are critical to cell protection from toxins, both endogenous and environmental, including a number of anti-cancer cytotoxic agents.Enhancing GSH and associated enzymes represents a longtime and persistent aim in the search for cytoprotective strategies against cancer, neurologic degeneration, pulmonary and inflammatory conditions, as well as cardiovascular ailments. The challenge is to identify effective GSH analogues or precursors that generate mimic molecules with glutathione's cellular protective effects. This review will provide an update on these efforts. Much effort has also been directed at depleting cellular GSH and related cytoprotective effects, in order to sensitize established tumors to the cytotoxic effects of anti-cancer agents. Efforts to deplete GSH have been limited by the challenge of selectivity doing so in tumor and not in normal tissue so as to avoid enhancing the toxicity of anti-cancer drugs. This review will also provide an update of efforts at overcoming the challenge of targeting the desired GSH depletion to tumor cells.This chapter provides a brief background and update of progress in the development and use of GSH analogues in the therapeutic setting, including the pharmacological aspects of these compounds.This is an area of enormous research activity, and major advances promise the advent of novel therapeutic opportunities in the near future. This article is part of a Special Issue entitled Cellular functions of glutathione." @default.
• W2072548201 created "2016-06-24" @default.
• W2072548201 creator A5029097581 @default.
• W2072548201 creator A5066108947 @default.
• W2072548201 date "2013-05-01" @default.
• W2072548201 modified "2023-09-30" @default.
• W2072548201 title "Glutathione and glutathione analogues; Therapeutic potentials" @default.
• W2072548201 cites W1481734539 @default.
• W2072548201 cites W1522955826 @default.
• W2072548201 cites W1660272883 @default.
• W2072548201 cites W1675853404 @default.
• W2072548201 cites W1970219610 @default.
• W2072548201 cites W1978892575 @default.
• W2072548201 cites W1980495957 @default.
• W2072548201 cites W1981904952 @default.
• W2072548201 cites W1987140480 @default.
• W2072548201 cites W1988833781 @default.
• W2072548201 cites W1999606080 @default.
• W2072548201 cites W2001174028 @default.
• W2072548201 cites W2011022006 @default.
• W2072548201 cites W2012907539 @default.
• W2072548201 cites W2029805131 @default.
• W2072548201 cites W2031082710 @default.
• W2072548201 cites W2049816734 @default.
• W2072548201 cites W2057490489 @default.
• W2072548201 cites W2086119574 @default.
• W2072548201 cites W2090529071 @default.
• W2072548201 cites W2092961621 @default.
• W2072548201 cites W2095532750 @default.
• W2072548201 cites W2103860275 @default.
• W2072548201 cites W2147595835 @default.
• W2072548201 cites W2151272921 @default.
• W2072548201 cites W2153249134 @default.
• W2072548201 cites W2169975628 @default.
• W2072548201 cites W2320525009 @default.
• W2072548201 doi "https://doi.org/10.1016/j.bbagen.2012.11.016" @default.
• W2072548201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23201199" @default.
• W2072548201 hasPublicationYear "2013" @default.
• W2072548201 type Work @default.
• W2072548201 sameAs 2072548201 @default.
• W2072548201 citedByCount "88" @default.
• W2072548201 countsByYear W20725482012013 @default.
• W2072548201 countsByYear W20725482012014 @default.
• W2072548201 countsByYear W20725482012015 @default.
• W2072548201 countsByYear W20725482012016 @default.
• W2072548201 countsByYear W20725482012017 @default.
• W2072548201 countsByYear W20725482012018 @default.
• W2072548201 countsByYear W20725482012019 @default.
• W2072548201 countsByYear W20725482012020 @default.
• W2072548201 countsByYear W20725482012021 @default.
• W2072548201 countsByYear W20725482012022 @default.
• W2072548201 countsByYear W20725482012023 @default.
• W2072548201 crossrefType "journal-article" @default.
• W2072548201 hasAuthorship W2072548201A5029097581 @default.
• W2072548201 hasAuthorship W2072548201A5066108947 @default.
• W2072548201 hasConcept C121608353 @default.
• W2072548201 hasConcept C126322002 @default.
• W2072548201 hasConcept C154317977 @default.
• W2072548201 hasConcept C181199279 @default.
• W2072548201 hasConcept C185592680 @default.
• W2072548201 hasConcept C202751555 @default.
• W2072548201 hasConcept C502942594 @default.
• W2072548201 hasConcept C538909803 @default.
• W2072548201 hasConcept C55493867 @default.
• W2072548201 hasConcept C71924100 @default.
• W2072548201 hasConcept C86803240 @default.
• W2072548201 hasConcept C96232424 @default.
• W2072548201 hasConcept C98274493 @default.
• W2072548201 hasConceptScore W2072548201C121608353 @default.
• W2072548201 hasConceptScore W2072548201C126322002 @default.
• W2072548201 hasConceptScore W2072548201C154317977 @default.
• W2072548201 hasConceptScore W2072548201C181199279 @default.
• W2072548201 hasConceptScore W2072548201C185592680 @default.
• W2072548201 hasConceptScore W2072548201C202751555 @default.
• W2072548201 hasConceptScore W2072548201C502942594 @default.
• W2072548201 hasConceptScore W2072548201C538909803 @default.
• W2072548201 hasConceptScore W2072548201C55493867 @default.
• W2072548201 hasConceptScore W2072548201C71924100 @default.
• W2072548201 hasConceptScore W2072548201C86803240 @default.
• W2072548201 hasConceptScore W2072548201C96232424 @default.
• W2072548201 hasConceptScore W2072548201C98274493 @default.
• W2072548201 hasIssue "5" @default.
• W2072548201 hasLocation W20725482011 @default.
• W2072548201 hasLocation W20725482012 @default.
• W2072548201 hasOpenAccess W2072548201 @default.
• W2072548201 hasPrimaryLocation W20725482011 @default.
• W2072548201 hasRelatedWork W1263321344 @default.
• W2072548201 hasRelatedWork W162897110 @default.
• W2072548201 hasRelatedWork W1769442777 @default.
• W2072548201 hasRelatedWork W1969419384 @default.
• W2072548201 hasRelatedWork W1982365147 @default.
• W2072548201 hasRelatedWork W2040969209 @default.
• W2072548201 hasRelatedWork W2043643409 @default.
• W2072548201 hasRelatedWork W2064587910 @default.
• W2072548201 hasRelatedWork W2163536072 @default.
• W2072548201 hasRelatedWork W2079932508 @default.
• W2072548201 hasVolume "1830" @default.
• W2072548201 isParatext "false" @default.

• next