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- W2072552003 abstract "Oxidative stress plays an important role in the pathogenesis of hypertension. A number of sources of reactive oxygen species have been identified including NADPH oxidase, endothelial NO synthase, and xanthine oxidase. Inhibitors of these systems reduce blood pressure in experimental models. Targeted overexpression of antioxidant systems and interference with expression of oxidant systems has also been successfully used in animal models of hypertension. It is expected that these strategies will eventually be translated to human disease, but currently, the specificity and toxicity of such measures are not yet fulfilling quality criteria for treatment of humans. In the meantime, presumably nontoxic measures, such as administration of antioxidant vitamins, are the only available treatments for oxidative stress in humans. In this review, we discuss strategies to target oxidative stress both in experimental models and in humans. We also discuss how patients could be selected who particularly benefit from antioxidant treatment. In clinical practice, diagnostic procedures beyond measurement of blood pressure will be necessary to predict the response to antioxidants; these procedures will include measurement of antioxidant status and detailed assessment of vascular structure and function." @default.
- W2072552003 created "2016-06-24" @default.
- W2072552003 creator A5017081040 @default.
- W2072552003 creator A5038005055 @default.
- W2072552003 creator A5040449404 @default.
- W2072552003 date "2008-06-01" @default.
- W2072552003 modified "2023-09-27" @default.
- W2072552003 title "Targeting Reactive Oxygen Species in Hypertension" @default.
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